Illustration of initial and follow-up visit angiograms obtained from one single participant. Figure 1a depicts the index angiogram while Figure 1b is the follow-up angiogram from the same angle. To visualize the coronary lesions progression, two sets of colored arrows were presented to manifest different lesions. In addition, both lesions progressed during the 1 year follow-up. Figures were obtained with permission from the catheter lab at the Shanghai Ruijin Hospital, affiliated to Shanghai Jiaotong University School of Medicine.