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Table 3 Medication and association with HbA1c

From: Characteristics of poorly controlled Type 2 diabetes patients in Swiss primary care

  Mean ± SD or n (%) Association with HbA1c1)
Coefficient P-value
Anitdiabetic therapy 312 (96.6)   0.022 c), 3d)
 None (n, %) 12 (3.7)   
 Only oral (n, %) 2) 208 (64.4)   
 Only insulin (n, %) 2) 26 (8.0)   
 Combined (insulin and oral) (n, %) 2) 77 (23.8)   
Specific antidiabetic therapies    
 Insulin (n, %) 103 (31.9)   0.005 b), 3e)
 Metformin/Biguanid (%) 254 (78.6)   0.384 b)
 Sulfonylurea (n, %) 136 (42.1)   0.764 b)
 Gliptine (DPP-III) (n, %) 44 (13.6)   0.425 b)
 Glitazone (n, %) 19 (5.9)   0.553 b)
 Glinide (n, %) 10 (3.1)   0.160 b)
 Incretin mimetic (n, %) 6 (1.9)   0.090 b) 3f)
 α-Glucosidase inhibitor (n, %) 4 (1.2)   0.837 b)
Any antihypertensive agent (n, %) 2) 246 (76.2)   0.098 b), 3g)
 Diuretics (n, %) 160 (49.5)   0.317 b)
 Inhibitor of the angiotensin converting enzyme (ACE-I) (n, %) 156 (48.3)   0.213 b)
 Beta-blocker (n, %) 101 (31.3)   0.321 b)
 Angiotensin II inhibitor (ARB) (n, %) 70 (21.7)   0.787 b)
 Calcium antagonists (n, %) 64 (19.8)   0.135 b)
 others (n, %) 4 (1.2)   0.838 b)
Any antiplatelet therapy (n, %) 2) 179 (55.4)   0.700 b)
 Aspirin (n, %) 158 (48.9)   0.869 b)
 Phenprocoumon (n, %) 21 (6.5)   0.017 b), 3h)
 Clopidogrel (n, %) 17 (5.3)   0.505 b)
Any lipid-lowering therapy (n, %) 2) 182 (56.3)   0.005 b), 3i)
Any antidepressants (n, %) 37 (11.5)   0.751 b)
Number of drugs total 4.8 (2.1) -0.052 0.349 a)
  1. 1) a) Associations HbA1c with continuous variables by Pearson correlations, between HbA1c and categorical variables by b) t-tests and c) ANOVA.
  2. 2) 1 or more drugs possible.
  3. 3) HbA1c (%) mean per category of significant t-test and ANOVA results (p < 0.010): d) Anitdiabetic therapy: none = 7.2, only oral = 7.6, only insulin = 7.8, combined (insulin and oral) = 8.0; e) Insulin: yes = 8.0, no = 7.6; f) Incretin mimetic: yes = 8.6, no = 7.7; g) Any antihypertensive agent: yes = 7.6, no = 8.0; h) Phenprocoumon: yes = 7.4, no = 7.7; i) Any lipid-lowering therapy: yes = 7.5, no = 7.9.