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Table 3 Medication and association with HbA1c

From: Characteristics of poorly controlled Type 2 diabetes patients in Swiss primary care

 

Mean ± SD or n (%)

Association with HbA1c1)

Coefficient

P-value

Anitdiabetic therapy

312 (96.6)

 

0.022 c), 3d)

 None (n, %)

12 (3.7)

  

 Only oral (n, %) 2)

208 (64.4)

  

 Only insulin (n, %) 2)

26 (8.0)

  

 Combined (insulin and oral) (n, %) 2)

77 (23.8)

  

Specific antidiabetic therapies

   

 Insulin (n, %)

103 (31.9)

 

0.005 b), 3e)

 Metformin/Biguanid (%)

254 (78.6)

 

0.384 b)

 Sulfonylurea (n, %)

136 (42.1)

 

0.764 b)

 Gliptine (DPP-III) (n, %)

44 (13.6)

 

0.425 b)

 Glitazone (n, %)

19 (5.9)

 

0.553 b)

 Glinide (n, %)

10 (3.1)

 

0.160 b)

 Incretin mimetic (n, %)

6 (1.9)

 

0.090 b) 3f)

 α-Glucosidase inhibitor (n, %)

4 (1.2)

 

0.837 b)

Any antihypertensive agent (n, %) 2)

246 (76.2)

 

0.098 b), 3g)

 Diuretics (n, %)

160 (49.5)

 

0.317 b)

 Inhibitor of the angiotensin converting enzyme (ACE-I) (n, %)

156 (48.3)

 

0.213 b)

 Beta-blocker (n, %)

101 (31.3)

 

0.321 b)

 Angiotensin II inhibitor (ARB) (n, %)

70 (21.7)

 

0.787 b)

 Calcium antagonists (n, %)

64 (19.8)

 

0.135 b)

 others (n, %)

4 (1.2)

 

0.838 b)

Any antiplatelet therapy (n, %) 2)

179 (55.4)

 

0.700 b)

 Aspirin (n, %)

158 (48.9)

 

0.869 b)

 Phenprocoumon (n, %)

21 (6.5)

 

0.017 b), 3h)

 Clopidogrel (n, %)

17 (5.3)

 

0.505 b)

Any lipid-lowering therapy (n, %) 2)

182 (56.3)

 

0.005 b), 3i)

Any antidepressants (n, %)

37 (11.5)

 

0.751 b)

Number of drugs total

4.8 (2.1)

-0.052

0.349 a)

  1. 1) a) Associations HbA1c with continuous variables by Pearson correlations, between HbA1c and categorical variables by b) t-tests and c) ANOVA.
  2. 2) 1 or more drugs possible.
  3. 3) HbA1c (%) mean per category of significant t-test and ANOVA results (p < 0.010): d) Anitdiabetic therapy: none = 7.2, only oral = 7.6, only insulin = 7.8, combined (insulin and oral) = 8.0; e) Insulin: yes = 8.0, no = 7.6; f) Incretin mimetic: yes = 8.6, no = 7.7; g) Any antihypertensive agent: yes = 7.6, no = 8.0; h) Phenprocoumon: yes = 7.4, no = 7.7; i) Any lipid-lowering therapy: yes = 7.5, no = 7.9.