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Table 2 Effect of hyperglycemia on infarct size

From: Effects of diabetes on myocardial infarct size and cardioprotection by preconditioning and postconditioning

Species Duration of hyperglycemia Blood sugar (mg/dl) Index ischemia   First author Journal
    min type   
Hyperglycemia
Infarct size enlargement
Dog before I 585 vs. 71 60 regional, vivo Kersten Am J Physiol 1998
Rabbit (NZ white) throughout 594 vs. 99 30 regional, vitro Wong J Diabetes Complications 2011
Rat (SD) during I 324 vs 85 30 regional, vivo Su Am J Physiol 2007
No change in infarct size
Dog before I 310 vs. 71 60 regional, vivo Kersten Am J Physiol 1998
Dog before I 310 vs. 75 60 regional, vivo Kersten Am J Physiol 2001
Dog before I 316, 579 vs. 78 60 regional, vivo Kehl Anesthesiology 2002
Dog before I 307 vs 83 60 regional, vivo Gu Anesthesiology 2008
Rabbit (NZ white) before and during I 660 vs. 185 30 regional, vivo Ebel Pflugers Arch 2003
Rabbit (NZ white) before I 257 vs 124 30 regional, vivo Amour Anesthesiology 2010
Rabbit (NZ white) before and during I 338 vs 142 40 regional, vivo Raphael J Cardiovasc Pharmacol 2010
Rat (SD) before and during I 360 vs 112 30 regional, vivo Ichinomiya Cardiovasc Diabetol 2012
Rat (Wistar) before and during I >400 vs. 121 25 regional, vivo Weber Eur J Pharmacol 2008
Rat (Wistar) before and during I 459 vs 128 25 regional, vivo Huhn Br J Anaesth 2008
Rat (Wistar) before and during I 355 vs 89 30 regional, vivo Matsumoto Cardiovasc Diabetol 2012
Metabolic syndrome
Infarct size enlargement
Rat (Wistar) Western diet for 16 w 95 vs 87 40 regional, vitro du Toit Am J Physiol 2008
No change in infarct size
Rat (SD) high fat diet for 13 w 160 vs 144 45 regional, vivo Thim Clin Sci (Lond) 2006
Rat (WOKW) (28 w old) 105 vs. ? 30 regional, vivo Wagner J Cardiovasc Pharmacol 2008
  1. NZ New Zealand, SD Sprague–Dawley, WOKW Wistar-Ottawa-Karlsburg W, before I before ischemia, during I during ischemia, w weeks.