Figure 4
From: GLUT4, GLUT1, and GLUT8 are the dominant GLUT transcripts expressed in the murine left ventricle
Relative expression of GLUT transcripts in the left ventricle of the TG9 model of dilated cardiomyopathy. Comparative real time PCR was performed to examine the relative mRNA expression of GLUT transcripts in left ventricles derived from A. 70-day-old and B. 85-day-old TG9 mice (TG9) and FVB/NJ controls (WT). Real time PCR shows that the expression levels of GLUT1 mRNA increase significantly in TG9 mice compared to age matched controls during heart failure progression. Conversely, the transcript levels for the insulin responsive glucose transporters GLUT4, GLUT8, and GLUT12 are significantly lower in heart from TG9 mice compared to FVB/NJ controls (n = 6–11 mice/group). *, P < 0.05.