Skip to main content

Table 5 Adjusted mean changes in laboratory parameters during exposure period from baseline by sex

From: Comparative effect of angiotensin II type I receptor blockers and calcium channel blockers on laboratory parameters in hypertensive patients with type 2 diabetes

Laboratory test

Adjusted Women

Adjusted Men

 

Mean

(95%CI)

p-value

Mean

(95%CI)

p-value

ΔTG (mmol/L)

CCB

-0.076

(-0.178, 0.025)

0.3449

-0.061

(-0.162, 0.039)

0.8484

ARB

-0.007

(-0.108, 0.095)

 

-0.047

(-0.148, 0.053)

 

ΔTC (mmol/L)

CCB

-0.127

(-0.239, -0.014)

0.2907

-0.117

(-0.19, -0.044)

0.9665

ARB

-0.214

(-0.326, -0.101)

 

-0.115

(-0.188, -0.042)

 

ΔBlood glucose (mmol/L)

CCB

-0.17

(-0.593, 0.253)

0.6908

-0.152

(-0.505, 0.202)

0.8447

ARB

-0.293

(-0.717, 0.131)

 

-0.101

(-0.454, 0.252)

 

ΔHbA1c (%)

CCB

-0.075

(-0.216, 0.066)

0.0777

-0.092

(-0.201, 0.016)

0.9247

ARB

-0.257

(-0.398, -0.116)

 

-0.1

(-0.208, 0.009)

 

ΔCreatinine (μmol/L)

CCB

0.475

(-0.776, 1.726)

0.0592

2.346

(-0.967, 5.658)

0.923

ARB

2.202

(0.948, 3.456)

 

2.578

(-0.73, 5.886)

 

ΔSodium (mmol/L)

CCB

-0.09

(-0.434, 0.254)

0.1124

-0.279

(-0.567, 0.009)

0.3479

ARB

-0.49

(-0.835, -0.145)

 

-0.082

(-0.37, 0.206)

 

ΔPotassium (mmol/L)

CCB

-0.015

(-0.067, 0.038)

0.0188 *

0.0002

(-0.041, 0.041)

0.2423

ARB

0.075

(0.023, 0.128)

 

0.035

(-0.006, 0.076)

 

ΔALT (U/L)

CCB

-0.921

(-3.478, 1.636)

0.1991

-0.31

(-2.767, 2.147)

0.5436

ARB

-3.32

(-5.883, -0.758)

 

-1.393

(-3.847, 1.06)

 

ΔAST (U/L)

CCB

1.125

(-1.37, 3.621)

0.0796

0.59

(-1.334, 2.514)

0.6034

ARB

-2.43

(-4.931, 0.072)

 

-0.135

(-2.057, 1.786)

 

ΔGGT (U/L)

CCB

-1.498

(-6.821, 3.824)

0.3965

3.176

(-6.48, 12.832)

0.3908

ARB

-4.794

(-10.129, 0.541)

 

-2.839

(-12.482, 6.804)

 

ΔWBC (x109/L)

CCB

-0.092

(-0.278, 0.094)

0.3973

-0.02

(-0.191, 0.152)

0.7449

ARB

0.023

(-0.164, 0.209)

 

-0.06

(-0.232, 0.111)

 

ΔRBC (x1012/L)

CCB

-0.025

(-0.061, 0.012)

0.0004 *

-0.032

(-0.067, 0.003)

0.0286 *

ARB

-0.12

(-0.157, -0.083)

 

-0.088

(-0.123, -0.053)

 

ΔPLT(x109/L)

CCB

4.675

(-0.389, 9.738)

0.2057

4.86

(0.551, 9.17)

0.3242

ARB

-0.008

(-5.083, 5.067)

 

1.776

(-2.528, 6.08)

 

ΔHemoglobin (g/L)

CCB

-1.286

(-2.417, -0.156)

0.0135 *

-1.811

(-2.931, -0.692)

0.2222

ARB

-3.333

(-4.466, -2.2)

 

-2.804

(-3.922, -1.686)

 

ΔHematocrit (mmol/mol)

CCB

-0.002

(-0.006, 0.001)

0.0076 *

-0.003

(-0.006, 0.0004)

0.0796

ARB

-0.009

(-0.012, -0.005)

 

-0.007

(-0.01, -0.004)

 
  1. Δindicates mean change in laboratory test value between baseline and exposure period. Abbreviations: TG; triglyceride, TC; total cholesterol, HbA1c; hemoglobin A1c, ALT; alanine aminotransferase, AST; asparate aminotransferase, GGT; γ-glutamyltransferase, WBC; white blood cell count, RBC; red blood cell count, PLT; platelet count. *: p<0.05 (ARB vs CCB). † Analyses were adjusted by covariates including age, sex, medical history and previous drugs.
Back to article page

Cardiovascular Diabetology

ISSN: 1475-2840