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Table 5 Adjusted mean changes in laboratory parameters during exposure period from baseline by sex

From: Comparative effect of angiotensin II type I receptor blockers and calcium channel blockers on laboratory parameters in hypertensive patients with type 2 diabetes

Laboratory test Adjusted Women Adjusted Men
  Mean (95%CI) p-value Mean (95%CI) p-value
ΔTG (mmol/L)
CCB -0.076 (-0.178, 0.025) 0.3449 -0.061 (-0.162, 0.039) 0.8484
ARB -0.007 (-0.108, 0.095)   -0.047 (-0.148, 0.053)  
ΔTC (mmol/L)
CCB -0.127 (-0.239, -0.014) 0.2907 -0.117 (-0.19, -0.044) 0.9665
ARB -0.214 (-0.326, -0.101)   -0.115 (-0.188, -0.042)  
ΔBlood glucose (mmol/L)
CCB -0.17 (-0.593, 0.253) 0.6908 -0.152 (-0.505, 0.202) 0.8447
ARB -0.293 (-0.717, 0.131)   -0.101 (-0.454, 0.252)  
ΔHbA1c (%)
CCB -0.075 (-0.216, 0.066) 0.0777 -0.092 (-0.201, 0.016) 0.9247
ARB -0.257 (-0.398, -0.116)   -0.1 (-0.208, 0.009)  
ΔCreatinine (μmol/L)
CCB 0.475 (-0.776, 1.726) 0.0592 2.346 (-0.967, 5.658) 0.923
ARB 2.202 (0.948, 3.456)   2.578 (-0.73, 5.886)  
ΔSodium (mmol/L)
CCB -0.09 (-0.434, 0.254) 0.1124 -0.279 (-0.567, 0.009) 0.3479
ARB -0.49 (-0.835, -0.145)   -0.082 (-0.37, 0.206)  
ΔPotassium (mmol/L)
CCB -0.015 (-0.067, 0.038) 0.0188 * 0.0002 (-0.041, 0.041) 0.2423
ARB 0.075 (0.023, 0.128)   0.035 (-0.006, 0.076)  
ΔALT (U/L)
CCB -0.921 (-3.478, 1.636) 0.1991 -0.31 (-2.767, 2.147) 0.5436
ARB -3.32 (-5.883, -0.758)   -1.393 (-3.847, 1.06)  
ΔAST (U/L)
CCB 1.125 (-1.37, 3.621) 0.0796 0.59 (-1.334, 2.514) 0.6034
ARB -2.43 (-4.931, 0.072)   -0.135 (-2.057, 1.786)  
ΔGGT (U/L)
CCB -1.498 (-6.821, 3.824) 0.3965 3.176 (-6.48, 12.832) 0.3908
ARB -4.794 (-10.129, 0.541)   -2.839 (-12.482, 6.804)  
ΔWBC (x109/L)
CCB -0.092 (-0.278, 0.094) 0.3973 -0.02 (-0.191, 0.152) 0.7449
ARB 0.023 (-0.164, 0.209)   -0.06 (-0.232, 0.111)  
ΔRBC (x1012/L)
CCB -0.025 (-0.061, 0.012) 0.0004 * -0.032 (-0.067, 0.003) 0.0286 *
ARB -0.12 (-0.157, -0.083)   -0.088 (-0.123, -0.053)  
ΔPLT(x109/L)
CCB 4.675 (-0.389, 9.738) 0.2057 4.86 (0.551, 9.17) 0.3242
ARB -0.008 (-5.083, 5.067)   1.776 (-2.528, 6.08)  
ΔHemoglobin (g/L)
CCB -1.286 (-2.417, -0.156) 0.0135 * -1.811 (-2.931, -0.692) 0.2222
ARB -3.333 (-4.466, -2.2)   -2.804 (-3.922, -1.686)  
ΔHematocrit (mmol/mol)
CCB -0.002 (-0.006, 0.001) 0.0076 * -0.003 (-0.006, 0.0004) 0.0796
ARB -0.009 (-0.012, -0.005)   -0.007 (-0.01, -0.004)  
  1. Δindicates mean change in laboratory test value between baseline and exposure period. Abbreviations: TG; triglyceride, TC; total cholesterol, HbA1c; hemoglobin A1c, ALT; alanine aminotransferase, AST; asparate aminotransferase, GGT; γ-glutamyltransferase, WBC; white blood cell count, RBC; red blood cell count, PLT; platelet count. *: p<0.05 (ARB vs CCB). † Analyses were adjusted by covariates including age, sex, medical history and previous drugs.