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Table 3 Unadjusted and adjusted mean (95% CI) laboratory test values according to ARB or CCB use after propensity score matching

From: Comparative effect of angiotensin II type I receptor blockers and calcium channel blockers on laboratory parameters in hypertensive patients with type 2 diabetes

Laboratory test ARBs (n = 601) CCBs (n = 601)
Unadjusted Adjusted† Unadjusted Adjusted†
  Mean (95%CI) p-value Mean (95%CI) p-value Mean (95%CI) p-value Mean (95%CI) p-value
TG (mmol/L)
baseline 1.65 (1.56, 1.73) 0.5113 1.65 (1.56, 1.73) 0.4846 1.63 (1.56, 1.71) 0.2961 1.63 (1.56, 1.7) 0.2604
exposure 1.60 (1.52, 1.69)   1.6 (1.52, 1.69)   1.57 (1.5, 1.65)   1.57 (1.5, 1.65)  
TC (mmol/L)
baseline 5.20 (5.12, 5.28) 0.0056 * 5.2 (5.13, 5.27) 0.0018 * 5.18 (5.1, 5.26) 0.0351 * 5.18 (5.11, 5.25) 0.0206 *
exposure 5.05 (4.97, 5.12)   5.05 (4.98, 5.12)   5.06 (4.98, 5.14)   5.06 (4.99, 5.13)  
Blood glucose (mmol/L)
baseline 7.88 (7.63, 8.13) 0.3744 7.88 (7.66, 8.1) 0.3133 7.96 (7.7, 8.23) 0.3809 7.96 (7.72, 8.2) 0.3257
exposure 7.72 (7.47, 7.97)   7.72 (7.5, 7.94)   7.79 (7.53, 8.06)   7.79 (7.55, 8.03)  
HbA1c (%)
baseline 6.97 (6.86, 7.08) 0.0451 * 6.97 (6.88, 7.05) 0.0074 * 6.93 (6.81, 7.05) 0.2981 6.93 (6.84, 7.02) 0.1793
exposure 6.81 (6.7, 6.92)   6.81 (6.73, 6.89)   6.84 (6.73, 6.96)   6.84 (6.75, 6.93)  
Creatinine (μmol/L)
baseline 72.8 (70, 75.5) 0.2045 72.8 (70.7, 74.8) 0.0934 73.8 (70, 77.7) 0.5707 73.8 (71.3, 76.4) 0.3887
exposure 75.3 (72.5, 78)   75.3 (73.2, 77.3)   75.4 (71.5, 79.2)   75.4 (72.9, 77.9)  
Sodium (mmol/L)
baseline 141.4 (141.2, 141.6) 0.1841 141.4 (141.2, 141.6) 0.1725 141.9 (141.7, 142.1)` 0.1137 141.9 (141.7, 142.1) 0.0993
exposure 141.2 (141, 141.4)   141.2 (141, 141.4)   141.7 (141.5, 141.9)   141.7 (141.5, 141.9)  
Potassium (mmol/L)
baseline 4.39 (4.36, 4.42) 0.0351 * 4.39 (4.36, 4.42) 0.0241 * 4.3 (4.26, 4.33) 0.8344 4.3 (4.26, 4.33) 0.8298
exposure 4.44 (4.41, 4.47)   4.44 (4.41, 4.47)   4.29 (4.26, 4.32)   4.29 (4.26, 4.32)  
ALT (U/L)
baseline 27.2 (25.5, 28.8) 0.0903 27.2 (25.7, 28.6) 0.0577 28.5 (26.4, 30.7) 0.6781 28.5 (26.6, 30.5) 0.6465
exposure 25.2 (23.5, 26.8)   25.2 (23.7, 26.6)   27.9 (25.8, 30)   27.9 (26, 29.8)  
AST (U/L)
baseline 27.3 (26, 28.6) 0.3521 27.3 (26.1, 28.4) 0.3041 28.2 (26.4, 30) 0.6099 28.2 (26.6, 29.9) 0.5741
exposure 26.4 (25.1, 27.7)   26.4 (25.2, 27.6)   28.9 (27.1, 30.7)   28.9 (27.2, 30.5)  
GGT (U/L)
baseline 53.2 (46.8, 59.6) 0.4179 53.2 (47.1, 59.4) 0.3967 56.1 (49.3, 62.8) 0.7434 56.1 (49.7, 62.5) 0.7292
exposure 49.5 (43.1, 55.9)   49.5 (43.4, 55.6)   57.7 (50.9, 64.4)   57.7 (51.3, 64.1)  
WBC (x109/L)
baseline 6.36 (6.21, 6.51) 0.8579 6.36 (6.22, 6.5) 0.8494 6.47 (6.32, 6.63) 0.6118 6.47 (6.33, 6.62) 0.5847
exposure 6.34 (6.19, 6.49)   6.34 (6.2, 6.48)   6.42 (6.26, 6.57)   6.42 (6.27, 6.56)  
RBC (x1012/L)
baseline 4.36 (4.32, 4.4) 0.0015 * 4.36 (4.33, 4.4) 0.0002 * 4.4 (4.36, 4.45) 0.3324 4.4 (4.36, 4.45) 0.2798
exposure 4.26 (4.22, 4.31)   4.26 (4.23, 4.3)   4.37 (4.33, 4.42)   4.37 (4.33, 4.41)  
PLT (x109/L)
baseline 221.2 (216.4, 226) 0.8006 221.2 (216.8, 225.6) 0.7845 222.4 (216.8, 227.9) 0.2089 222.4 (217.2, 227.6) 0.1825
exposure 222.1 (217.3, 226.9)   222.1 (217.7, 226.5)   227.4 (221.9, 233)   227.4 (222.2, 232.6)  
Hemoglobin (g/L)
baseline 138.0 (136.7, 139.4) 0.0024 * 138 (136.9, 139.1) 0.0002 * 138.5 (137.1, 139.8) 0.0727 138.5 (137.4, 139.6) 0.0315 *
exposure 135.1 (133.8, 136.5)   135.1 (134, 136.2)   136.7 (135.4, 138.1)   136.7 (135.6, 137.9)  
Hematocrit (mmol/mol)
baseline 0.407 (0.404, 0.411) 0.0069 * 0.407 (0.404, 0.411) 0.0012 * 0.409 (0.405, 0.413) 0.285 0.409 (0.406, 0.412) 0.2033
exposure 0.400 (0.396, 0.404)   0.4 (0.397, 0.403)   0.406 (0.402, 0.41)   0.406 (0.403, 0.409)  
  1. Abbreviations: TG; triglyceride, TC; total cholesterol, HbA1c; hemoglobin A1c, ALT; alanine aminotransferase, AST; asparate aminotransferase, GGT; γ-glutamyltrasnferase, WBC; white blood cell count, RBC; red blood cell count, PLT; platelet count. *: p<0.05 (baseline vs exposure). † Analyses were adjusted by covariates including age, sex, medical history and previous medication.