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Table 3 Unadjusted and adjusted mean (95% CI) laboratory test values according to ARB or CCB use after propensity score matching

From: Comparative effect of angiotensin II type I receptor blockers and calcium channel blockers on laboratory parameters in hypertensive patients with type 2 diabetes

Laboratory test

ARBs (n = 601)

CCBs (n = 601)

Unadjusted

Adjusted†

Unadjusted

Adjusted†

 

Mean

(95%CI)

p-value

Mean

(95%CI)

p-value

Mean

(95%CI)

p-value

Mean

(95%CI)

p-value

TG (mmol/L)

baseline

1.65

(1.56, 1.73)

0.5113

1.65

(1.56, 1.73)

0.4846

1.63

(1.56, 1.71)

0.2961

1.63

(1.56, 1.7)

0.2604

exposure

1.60

(1.52, 1.69)

 

1.6

(1.52, 1.69)

 

1.57

(1.5, 1.65)

 

1.57

(1.5, 1.65)

 

TC (mmol/L)

baseline

5.20

(5.12, 5.28)

0.0056 *

5.2

(5.13, 5.27)

0.0018 *

5.18

(5.1, 5.26)

0.0351 *

5.18

(5.11, 5.25)

0.0206 *

exposure

5.05

(4.97, 5.12)

 

5.05

(4.98, 5.12)

 

5.06

(4.98, 5.14)

 

5.06

(4.99, 5.13)

 

Blood glucose (mmol/L)

baseline

7.88

(7.63, 8.13)

0.3744

7.88

(7.66, 8.1)

0.3133

7.96

(7.7, 8.23)

0.3809

7.96

(7.72, 8.2)

0.3257

exposure

7.72

(7.47, 7.97)

 

7.72

(7.5, 7.94)

 

7.79

(7.53, 8.06)

 

7.79

(7.55, 8.03)

 

HbA1c (%)

baseline

6.97

(6.86, 7.08)

0.0451 *

6.97

(6.88, 7.05)

0.0074 *

6.93

(6.81, 7.05)

0.2981

6.93

(6.84, 7.02)

0.1793

exposure

6.81

(6.7, 6.92)

 

6.81

(6.73, 6.89)

 

6.84

(6.73, 6.96)

 

6.84

(6.75, 6.93)

 

Creatinine (μmol/L)

baseline

72.8

(70, 75.5)

0.2045

72.8

(70.7, 74.8)

0.0934

73.8

(70, 77.7)

0.5707

73.8

(71.3, 76.4)

0.3887

exposure

75.3

(72.5, 78)

 

75.3

(73.2, 77.3)

 

75.4

(71.5, 79.2)

 

75.4

(72.9, 77.9)

 

Sodium (mmol/L)

baseline

141.4

(141.2, 141.6)

0.1841

141.4

(141.2, 141.6)

0.1725

141.9

(141.7, 142.1)`

0.1137

141.9

(141.7, 142.1)

0.0993

exposure

141.2

(141, 141.4)

 

141.2

(141, 141.4)

 

141.7

(141.5, 141.9)

 

141.7

(141.5, 141.9)

 

Potassium (mmol/L)

baseline

4.39

(4.36, 4.42)

0.0351 *

4.39

(4.36, 4.42)

0.0241 *

4.3

(4.26, 4.33)

0.8344

4.3

(4.26, 4.33)

0.8298

exposure

4.44

(4.41, 4.47)

 

4.44

(4.41, 4.47)

 

4.29

(4.26, 4.32)

 

4.29

(4.26, 4.32)

 

ALT (U/L)

baseline

27.2

(25.5, 28.8)

0.0903

27.2

(25.7, 28.6)

0.0577

28.5

(26.4, 30.7)

0.6781

28.5

(26.6, 30.5)

0.6465

exposure

25.2

(23.5, 26.8)

 

25.2

(23.7, 26.6)

 

27.9

(25.8, 30)

 

27.9

(26, 29.8)

 

AST (U/L)

baseline

27.3

(26, 28.6)

0.3521

27.3

(26.1, 28.4)

0.3041

28.2

(26.4, 30)

0.6099

28.2

(26.6, 29.9)

0.5741

exposure

26.4

(25.1, 27.7)

 

26.4

(25.2, 27.6)

 

28.9

(27.1, 30.7)

 

28.9

(27.2, 30.5)

 

GGT (U/L)

baseline

53.2

(46.8, 59.6)

0.4179

53.2

(47.1, 59.4)

0.3967

56.1

(49.3, 62.8)

0.7434

56.1

(49.7, 62.5)

0.7292

exposure

49.5

(43.1, 55.9)

 

49.5

(43.4, 55.6)

 

57.7

(50.9, 64.4)

 

57.7

(51.3, 64.1)

 

WBC (x109/L)

baseline

6.36

(6.21, 6.51)

0.8579

6.36

(6.22, 6.5)

0.8494

6.47

(6.32, 6.63)

0.6118

6.47

(6.33, 6.62)

0.5847

exposure

6.34

(6.19, 6.49)

 

6.34

(6.2, 6.48)

 

6.42

(6.26, 6.57)

 

6.42

(6.27, 6.56)

 

RBC (x1012/L)

baseline

4.36

(4.32, 4.4)

0.0015 *

4.36

(4.33, 4.4)

0.0002 *

4.4

(4.36, 4.45)

0.3324

4.4

(4.36, 4.45)

0.2798

exposure

4.26

(4.22, 4.31)

 

4.26

(4.23, 4.3)

 

4.37

(4.33, 4.42)

 

4.37

(4.33, 4.41)

 

PLT (x109/L)

baseline

221.2

(216.4, 226)

0.8006

221.2

(216.8, 225.6)

0.7845

222.4

(216.8, 227.9)

0.2089

222.4

(217.2, 227.6)

0.1825

exposure

222.1

(217.3, 226.9)

 

222.1

(217.7, 226.5)

 

227.4

(221.9, 233)

 

227.4

(222.2, 232.6)

 

Hemoglobin (g/L)

baseline

138.0

(136.7, 139.4)

0.0024 *

138

(136.9, 139.1)

0.0002 *

138.5

(137.1, 139.8)

0.0727

138.5

(137.4, 139.6)

0.0315 *

exposure

135.1

(133.8, 136.5)

 

135.1

(134, 136.2)

 

136.7

(135.4, 138.1)

 

136.7

(135.6, 137.9)

 

Hematocrit (mmol/mol)

baseline

0.407

(0.404, 0.411)

0.0069 *

0.407

(0.404, 0.411)

0.0012 *

0.409

(0.405, 0.413)

0.285

0.409

(0.406, 0.412)

0.2033

exposure

0.400

(0.396, 0.404)

 

0.4

(0.397, 0.403)

 

0.406

(0.402, 0.41)

 

0.406

(0.403, 0.409)

 
  1. Abbreviations: TG; triglyceride, TC; total cholesterol, HbA1c; hemoglobin A1c, ALT; alanine aminotransferase, AST; asparate aminotransferase, GGT; γ-glutamyltrasnferase, WBC; white blood cell count, RBC; red blood cell count, PLT; platelet count. *: p<0.05 (baseline vs exposure). † Analyses were adjusted by covariates including age, sex, medical history and previous medication.
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Cardiovascular Diabetology

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