Cardiovascular Diabetology

Table 4 Association of UCP2 haplotypes with disease traits

From: Uncoupling protein 2 gene polymorphisms are associated with obesity

Additive Model
Haplotype	f	High BMI		High FPG		High TG		Low HDL-C		High LDL-C		High TC
		Est.	p	Est.	p	Est.	p	Est.	p	Est.	p	Est.	p
GC	0.56
AC	0.09	−0.05	0.902	0.82	0.280	−0.23	0.696	−0.58	0.325	−0.48	0.461	−0.65	0.315
AT	0.34	−0.21	0.312	0.33	0.444	0.11	0.676	−0.37	0.211	0.00	0.996	0.21	0.379
GT	0.01	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
Age		−0.01	0.222	0.05	<0.001	−0.02	0.109	0.01	0.335	0.02	0.086	0.01	0.024
Male		0.46	0.013	0.55	0.155	0.80	0.002	−1.89	<0.001	0.22	0.419	0.25	0.310
Urban		0.74	0.013	0.89	0.218	0.10	0.805	0.90	0.053	0.62	0.135	0.46	0.247
AC-urban		0.24	0.643	0.19	0.835	0.98	0.160	0.97	0.191	−0.44	0.612	−0.04	0.960
AT-urban		0.61	0.032	0.18	0.745	−0.04	0.912	0.49	0.228	−0.40	0.329	−0.42	0.261
GT-urban		NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
Dominant Model
Haplotype	f	High BMI		High FPG		High TG		Low HDL-C		High LDL-C		High TC
		Est.	p	Est.	p	Est.	p	Est.	p	Est.	p	Est.	p
GC	0.56
AC	0.09	0.05	0.900	0.77	0.341	−0.19	0.761	−0.60	0.336	−0.49	0.465	−0.64	0.337
AT	0.34	−0.14	0.644	0.26	0.701	0.18	0.644	−0.50	0.303	−0.05	0.882	0.28	0.450
GT	0.01	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
Age		−0.01	0.234	0.05	<0.001	−0.01	0.112	0.01	0.323	0.02	0.100	0.02	0.025
Male		0.46	0.017	0.53	0.168	0.80	0.002	−1.89	<0.001	0.22	0.403	0.25	0.309
Urban		0.67	0.038	1.04	0.155	−0.08	0.852	0.72	0.171	0.54	0.228	0.41	0.341
AC-urban		0.18	0.739	0.09	0.927	1.04	0.146	0.89	0.247	−0.38	0.668	0.00	1.000
AT-urban		0.89	0.024	−0.01	0.987	0.24	0.637	0.34	0.577	−0.33	0.548	−0.46	0.383
GT-urban		NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA

Logistic regression analysis for association of UCP2 haplotypes with diseases traits, assuming the additive and dominant genetic models, adjusted for age, gender, and population (urban/rural). Significant p values from Wald test were in bold. Analysis for a recessive model was not feasible due to low frequency of rare haplotype (<5%). Criteria: Obesity (high BMI ≥25 kg/m²) [34], High FPG (≥126 mg/dL) [36], high TG (200–499 mg/dL), low HDL-C (<40 mg/dL), high LDL-C (≥ 160 mg/dL), high TC (≥240 mg/dL) [37]. f: haplotype frequencies. NA: not available, data were omitted due to low haplotype frequencies (<5%).

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ISSN: 1475-2840

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