Uncoupling protein 2 gene polymorphisms are associated with obesity

Table 2 Genotypic and allelic distributions of rs659366 and rs659366 in non-obese and obese subjects

	Variables	All			Male			Female
		Urban	Rural	p	Urban	Rural	p	Urban	Rural	p
Non Obese	n	136	250		72	128		64	122
	G(−866)A (rs659366)
	G/G	0.40	0.29	0.065	0.36	0.23	0.055	0.45	0.34	0.177
	G/A	0.46	0.53		0.54	0.56		0.36	0.50
	A/A	0.14	0.18		0.10	0.20		0.19	0.16
	MAF (−866)A	0.37	0.45		0.37	0.48		0.37	0.41
	Heterozygosity	0.47	0.50		0.47	0.50		0.47	0.48
	A55V (rs660339)
	C/C	0.53	0.39	0.033	0.50	0.34	0.029	0.56	0.44	0.265
	C/T	0.36	0.43		0.42	0.45		0.30	0.41
	T/T	0.11	0.18		0.08	0.20		0.14	0.15
	MAF 55Val	0.29	0.39		0.29	0.43		0.29	0.35
	Heterozygosity	0.41	0.48		0.42	0.49		0.41	0.46
Obese	n	142	75		100	40		42	35
	G(−866)A (rs659366)
	G/G	0.27	0.29	0.585	0.28	0.28	0.968	0.24	0.31	0.151
	G/A	0.54	0.57		0.54	0.52		0.55	0.63
	A/A	0.19	0.13		0.18	0.20		0.21	0.06
	MAF (−866)A	0.46	0.42		0.45	0.46		0.49	0.37
	Heterozygosity	0.50	0.49		0.50	0.50		0.51	0.47
	A55V (rs660339)
	C/C	0.38	0.41	0.513	0.40	0.40	0.227	0.33	0.43	0.685
	C/T	0.54	0.47		0.52	0.42		0.57	0.51
	T/T	0.08	0.12		0.08	0.18		0.10	0.06
	MAF 55Val	0.35	0.35		0.34	0.39		0.38	0.31
	Heterozygosity	0.46	0.46		0.45	0.48		0.48	0.44

Obese criteria: BMI ≥25 kg/m² [34]. Statistical comparisons were calculated between the urban and rural populations in each category: genetic profiles were compared using Fisher’s exact test on 2x3 contingency table. Significant p values were in bold.

ISSN: 1475-2840