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Table 6 Joint association study to evaluate the risk of T2DM and CAD compared to controls

From: Apolipoprotein E gene polymorphism: effects on plasma lipids and risk of type 2 diabetes and coronary artery disease

Genotype

Obesity/Smoking

Controls

T2DM

Adjusted OR (95% CI)††

p-value

T2DM + CAD

Adjusted OR (95% CI)††

p-value

E3/E3

Neither

70

34

1

-

30

1

-

E3/E3

Either

40

73

3.65 (2.07 - 6.43)

<0.0001

56

2.24 (1.15 - 4.35)

0.018

E3/E3

Both

2

10

10.05 (2.06 - 48.96)

0.004

1

2.02 (0.16 - 25.01)

0.585

E3/E4

Neither

14

14

1.97 (0.84 - 4.64)

0.118

7

1.02 (0.34 - 3.06)

0.970

E3/E4

Either

6

15

4.93 (1.74 - 13.98)

0.003

36

10.48 (3.56 - 30.79)

<0.0001

E3/E4

Both

6

1

-

-

3

-

-

  1. †† After adjusting for age, sex and physical activity. Normal reference ranges of clinical and biochemical data are described in materials and methods.