|
Number
|
5978
|
2382
|
3596
|
|
ADRs
|
306 (5.1%)
|
103 (4.3%)
|
203 (5.6%)
|
|
Blood creatine phosphokinase increased
|
48 (0.8%)
|
17 (0.7%)
|
31 (0.9%)
|
|
Blood creatinine increased
|
46 (0.8%)
|
18 (0.8%)
|
28 (0.8%)
|
|
Blood urea increased
|
29 (0.5%)
|
10 (0.4%)
|
19 (0.5%)
|
|
Renal impairment
|
19 (0.3%)
|
8 (0.3%)
|
11 (0.3%)
|
|
Aspartate aminotransferase increased
|
18 (0.3%)
|
7 (0.3%)
|
11 (0.3%)
|
|
Myalgia
|
17 (0.3%)
|
6 (0.3%)
|
11 (0.3%)
|
|
Hepatic function abnormal
|
15 (0.3%)
|
2 (0.1%)
|
13 (0.4%)
|
|
Pruritus
|
13 (0.2%)
|
6 (0.3%)
|
7 (0.2%)
|
|
Alanine aminotransferase increased
|
13 (0.2%)
|
5 (0.2%)
|
8 (0.2%)
|
|
Rash
|
12 (0.2%)
|
6 (0.3%)
|
6 (0.2%)
|
|
Dyspepsia
|
7 (0.1%)
|
1 (0.0%)
|
6 (0.2%)
|
|
Others
|
72 (1.2%)
|
19 (0.8%)
|
53 (1.5%)
|
