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Table 1 Clinical and laboratory characteristics of individuals with type 1 diabetes, divided by HbA1 c quintiles

From: Heterogeneous behavior of lipids according to HbA1c levels undermines the plausibility of metabolic syndrome in type 1 diabetes: data from a nationwide multicenter survey

 

HbA1c quintiles

 
 

1st

2nd

3rd

4th

5th

 
 

≤ 7.4%

7.5 - 8.5%

8.6 - 9.6%

9.7 - 11.4%

≥ 11.5%

p

n

255

258

255

255

252

 

Age (years)

26.1 ± 12.0

26.7 ± 11.6

25.2 ± 11.4

23.9 ± 10.5

20.9 ± 9.1

< 0.05a

Duration of diabetes (years)

12.2 ± 10.1

12.9 ± 8.7

11.9 ± 7.9

10.5 ± 7.5

8.9 ± 6.4

< 0.05b

Total daily insulin dose (U)

45.6 ± 19.9

52.7 ± 22.8

55.2 ± 20.0

58.5 ± 21.5

62.1 ± 23.5

< 0.05c

BMI (kg/m2)

22.5 ± 3.7

23.2 ± 3.9

23.1 ± 3.9

22.8 ± 4.4

21.7 ± 3.8

< 0.05d

HbA1c (%)

6.6 ± 0.64

8.0 ± 0.32

9.1 ± 0.33

10.5 ± 0.55

13.6 ± 1.77

< 0.05e

Fasting plasma glucose (mmol/L)

7.77 ± 4.12

9.30 ± 5.23

10.68 ± 5.81

11.22 ± 5.81

12.96 ± 7.37

< 0.05f

Mean Blood Pressure (mmHg)

101.9 ± 12.8

100.9 ± 12.9

102.1 ± 13.4

101.2 ± 13.2

99.7 ± 12.8

NS

Total cholesterol (mmol/L)

4.08 ± 1.03

4.21 ± 1.05

4.34 ± 1.13

4.57 ± 1.01

4.86 ± 1.19

< 0.05g

HDL-cholesterol (mmol/L)

1.34 ± 0.46

1.38 ± 0.38

1.37 ± 0.34

1.43 ± 0.41

1.38 ± 0.37

NS

LDL-cholesterol (mmol/L)

2.31 ± 0.78

2.42 ± 0.79

2.53 ± 0.88

2.67 ± 0.86

2.90 ± 0.99

< 0.05h

Triglycerides (mmol/L)

0.92 ± 0.64

0.95 ± 0.72

1.00 ± 0.72

1.04 ± 0.70

1.31 ± 1.18

< 0.05a

Male gender (%)

49.0

46.9

42.7

39.6

36.9

0.034i

Statin users (%)

10.2

14.7

10.6

7.5

5.6

0.007i

Hypertriglyceridemia (%)

7.6

8.5

12.3

13.9

25.2

< 0.001i

Low HDL-cholesterol (%)

21.8

14.0

12.6

10.0

16.6

0.008i

High LDL-cholesterol (%)

31.6

34.2

40.4

50.0

57.2

< 0.001i

Microalbuminuria (%)

44.7

56.6

51.4

47.5

45.6

< 0.044i

Smokers (%)

4.7

6.6

4.7

2.4

6.7

NS

  1. a 5th quintile vs. all others; b 5th vs. 1st, 2nd, 3rd and 2nd vs. 4th quintiles; c 1st vs. all others, 2nd vs. 4th and 5th, 3rd vs. 5th quintiles; d 5th vs. 2nd, 3rd and 4th quintiles; e all pairwise comparisons; f 5th vs. all others; 1st vs. 3rd, 4th, 5th; 2nd vs. 4th quintile; g 1st vs. 4th and 5th; 2nd vs. 4th and 5th; 3rd vs. 5th quintiles; h 5th vs. 1st, 2nd, and 3rd; 4th vs. 1st quintiles; i 4 degrees-of-freedom significance; NS non-significant.