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Figure 7 | Cardiovascular Diabetology

Figure 7

From: Overexpression of steroidogenic acute regulatory protein in rat aortic endothelial cells attenuates palmitic acid-induced inflammation and reduction in nitric oxide bioavailability

Figure 7

The protective role of StAR in PA-induced endothelial dysfunction. In rat aortic endothelial cells, the key genes involved in lipid metabolism are greatly reduced following StAR overexpression. As a result, the cellular levels of cholesterol and FFAs are also reduced after StAR overexpression, which maintains the homeostasis of lipids. Levels of mRNA expression and secretion of inflammatory factors were significantly decreased after PA treatment, which is due to the blockade of NFκB nuclear translocation and activation after StAR overexpression. Moreover, the reduction of NO bioavailability induced by PA are compensated by StAR overexpression.

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Cardiovascular Diabetology

ISSN: 1475-2840