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Table 6 Cardiac element content and select gene expression at 6 wks after injection of STZ (HG) or vehicle (nonHG) in hypothyroid rats fed PTU diet or in euthyroid rats fed standard rat chow

From: Zinc-induced cardiomyocyte relaxation in a rat model of hyperglycemia is independent of myosin isoform

 

Hypothyroid

Euthyroid

 

 HG (n=8)

 nonHG (8)

HG (6)

nonHG (6)

Ca

101.2 ± 6.0

100.8 ± 7.4

284.4 ± 44.3*

155.4 ± 32.9

Cu

4.4 ± 0.2

3.9 ± 0.2

5.2 ± 0.3 *

6.4 ± 0.2

Fe

66.7 ± 3.0*

58.7 ± 1.9

95.5 ± 2.5 †

122.3 ± 7.5

K

2316 ± 148

2053 ± 85

7369 ± 793 *

5052 ± 566

Mg

186.8 ± 8.9

177.3 ± 7.6

275.1 ± 13.6

257.8 ± 6.0

Na

1863 ± 102

1788 ± 75

2325 ± 224 *

1641 ± 186

P

2158 ± 105

2012 ± 81

2726 ± 86

2711 ± 24

S

2545±155 *

2022 ± 102

3707 ± 163*

3149 ± 95

Zn

17.6 ± 0.7

17.7 ± 0.8

23.1 ± 1.1

22.2 ± 0.3

MT1a

-

-

0.66 ± 0.13 *

1.00 ± 0.05

ZnT2

-

-

0.76 ± 0.07 #

1.00 ± 0.10

γ-GCSh

-

-

1.30 ± 0.08 †

1.00 ± 0.03

  1. Concentration given in ppm: μg of element per g wet weight of LV. Gene expression given in RQ = 2-ΔΔCt. normalized to HPRT expression and then to mean of nonHG. Differences between HG and nonHG controls reported at *P<0.05, †P<0.01.