The impact of serum lipids on risk for microangiopathy in patients with type 2 diabetes mellitus

Table 3 Cox Proportional Hazard Models: HDL-C, LDL-C, TG and non-HDL-C and the First Microvascular Event

Primary Risk Factors of Interest¹	Lipid Panel²			Lipid Goal Attainment²
Primary Risk Factors of Interest¹	HR³	95 % CI	P-value	HR³	95 % CI	P-value
HDL-C	0.995	0.993 - 0.997	<.0001	0.895	0.852 - 0.941	<.0001
LDL-C	1.002	1.001 - 1.002	<.0001	0.909	0.865 - 0.955	.0001
TG	1.001	1.001 - 1.001	<.0001	0.849	0.808 - 0.892	<.0001
non-HDL-C	1.003	1.003 - 1.004	<.0001	0.8270	0.788 - 0.868	<.0001

¹ Four Cox proportional hazard models were run, two including HDL-C, LDL-C, and TG (lipid values and their goal attainment); the others with non-HDL-C lipid values and goal attainment as the primary risk factor of interest.
² The lipid panel values are derived from the last lab assessment results prior to the first microvascular (either retinopathy/nephropathy/neuropathy) event or censorship.
³ The HRs were obtained after controlling for the demographics (age, gender and state of residence), other index characteristics (health plan and physician type), pre-index health conditions (hypertension, obesity, heart failure, metabolic syndrome, renal disease, liver disease, ischemic heart disease, peripheral vascular disease, and depression), proportion of days covered during the follow up by the antihypertensives (ACEs, ARBs), and proportion of days covered by lipid altering therapies (statins [low, medium or high], niacin, ezetimibe, or fibrates [fenofibrates or genfibrozil]) between the last lipid panel measurement and event/censorship.
HR: hazard ratio; CI: confidence interval; LDL-C: low-density lipoprotein cholesterol; HDL-C: high-density lipoprotein cholesterol; TG: triglycerides.

ISSN: 1475-2840