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Table 3 Prognostic values of FRS and vascular assessments according to specified cut-off values

From: Prognostic implications of surrogate markers of atherosclerosis in low to intermediate risk patients with Type 2 Diabetes

Markers

AUC (SE)

Cut-off values

Sensitivity, % (95%CI)

Specificity, % (95 % CI)

PPV, %

NPV, %

FRS

0.59 ± 0.07

>2.56 %

82.4 (56.6-96.2)

47.8 (39.1-56.6)

16.7

95.5

FMD

0.59 ± 0.08

≤1.12 %

52.9 (27.8-77.0)

72.4 (64.0-79.8)

19.6

92.4

mmIMT

0.67 ± 0.07*

>1.07 mm

41.2 (18.4-67.1)

85.7 (78.6-91.2)

26.9

91.9

Carotid plaque

0.58 ± 0.06

-

70.6 (44.0-89.7)

45.11 (36.5-54.0)

14.1

92.3

ABI

0.64 ± 0.10

≤0.98

33.3 (9.9-65.1)

95.9 (88.5-99.1)

57.1

89.7

baPWV

0.63 ± 0.09

>1467 cm/s

100.0 (69.2-100.0)

26.4 (16.7-38.1)

15.9

100

CACS

0.81 ± 0.06**

>40

92.9 (66.1-99.8)

67.3 (57.8-75.8)

26.0

98.7

  1. Abbreviations as in Table 1 and AUC = area under curve; SE = standard error; CI = confidence interval; PPV = positive predictive value; NPV = negative predictive value*P < 0.05, **P < 0.01.