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Figure 5 | Cardiovascular Diabetology

Figure 5

From: Azelnidipine prevents cardiac dysfunction in streptozotocin-diabetic rats by reducing intracellular calcium accumulation, oxidative stress and apoptosis

Figure 5

Apoptosis in diabetic rat hearts and treated with AZL. A: representative photographs of in situ detection of apoptosis in heart tissue from controls, diabetic rats treated with vehicle, and diabetic rats treated with AZL (5 mg kg-1day-1). Total nuclei were labeled with DAPI (blue), and apoptotic nuclei were detected by TUNEL staining (green). B: average number of percent TUNEL-positive nuclei in tissue sections from each group (n = 4 to 5 sections each per group). *P < 0.05 vs. control group; **P < 0.05 vs. STZ treated group. C: Western blot showing bcl-2 expression in hearts from the same groups. Image is representative of the best of three separate experiments. β-actin served as loading control. Normalized densitometric quantification has been depicted by numerical value below the bands.

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Cardiovascular Diabetology

ISSN: 1475-2840