Skip to main content

Table 1 Baseline clinical characteristics

From: Concomitant renal insufficiency and diabetes mellitus as prognostic factors for acute myocardial infarction

 

Group I (n = 5700)

Group II (n = 1730)

Group III (n = 1431)

Group IV (n = 1044)

p Value

     

Overall

Linear†

Age (years)

61 ± 13

62 ± 11¶

71 ± 11

70 ± 9‡§

< 0.001

 

Age groups (years)

    

< 0.001

< 0.001

   < 65

2671(47%)

706(41%)

231(16%)

136(13%)

  

   65-74

2165(38%)

781(45%)

598(42%)

586(56%)

  

   ≥ 75

864(15%)

243(14%)

602(42%)

322(31%)

  

Male (%)

4411(77)

1222(71)¶

812(57)

534 (51)‡§

< 0.001

< 0.001

Body weight (kg)

65 ± 12

66 ± 12¶

61 ± 12

62 ± 11

0.095

 

Body mass index (kg/m2)

24 ± 3

25 ± 4¶

23 ± 3

24 ± 3§

0.483

 

HR(beats/minute)

76 ± 20

80 ± 20¶

79 ± 31

83 ± 26‡§

< 0.001

 

Systolic blood pressure(mm Hg)

130 ± 27

130 ± 28

121 ± 35

127 ± 34‡

< 0.001

 

Diastolic blood pressure(mm Hg)

80 ± 19

79 ± 16

74 ± 21

76 ± 35‡

< 0.001

 

Current smoker (%)

3690(65)

990(58)¶

660(46)

380(37)‡§

< 0.001

< 0.001

Treatment of Diabetes mellitus

      

   No treatment (%)

5700(100)

260(15.2)

1431(100)

65(7)‡

  

   Insulin treatment (%)

 

101(5.8)

 

160(15)‡

  

   Oral hypoglycemic agents (%)

 

1369(79)

 

819(78)

  

Previous hypertension (%)

2168(38)

987(57)¶

863(60)

772(74)‡§

< 0.001

< 0.001

Previous dyslipidemia (%)

497(9)

212(12)¶

118(8)

133(13)§

< 0.001

0.001

Family history of CAD (%)

446(8)

118(7)

63(4)

43(4)‡

< 0.001

< 0.001

Previous CAD (%)

684(12)

311(18)¶

293(21)

273(26)‡§

< 0.001

< 0.001

Killip class > I (%)

1099(20)

423 (25)¶

603 (43)

508 (50)‡§

< 0.001

< 0.001

LDL-C (mg/dl)

120 ± 40

114 ± 38¶

112 ± 43

110 ± 52‡

< 0.001

 

NT-proBNP (pg/ml)

323

(81, 1151)

468

(123, 1577)

1750 (338, 6804)

3522 (877, 10894)

< 0.001

 

hs-CRP

0.64 (0.17, 3.53)

0.92 (0.23, 4.15)

1.46 (0.30, 6.59)

2.19 (0.36, 9.70)

< 0.001

 

LVEF (%)

53 ± 12

51 ± 12¶

49 ± 14

46 ± 14‡§

< 0.001

 

STEMI (%)

3619(64)

1009(58)¶

908(63)

518(50)‡§

< 0.001

 

Non-STEMI (%)

2083(37)

722(42)¶

524(37)

526(50)‡§

< 0.001

 

Kidney function

      

   Serum Creatinine (mg/dL)

0.92 ± 0.19

0.91 ± 0.19¶

2.08 ± 3.58

2.38 ± 3.44‡§

< 0.001

 

   Estimated GFR* (ml/min/1.73 m2)

88.9 ± 39.2

87.5 ± 32.9

44.7 ± 14.2

39.0 ± 15.9‡§

< 0.001

 

Medications (%)

      

   Aspirin

5616 (99)

1706 (99)

1381 (97)

1009(97)‡

< 0.001

< 0.001

   Clopidogrel

5523(97)

1675(97)

1340(94)

968(93)‡

< 0.001

< 0.001

   Beta blocker

4295 (76)

1337 (78)

908 (64)

694 (67)‡

< 0.001

< 0.001

   CCB

707(12)

215(13)

205(14)

208(20)‡§

< 0.001

< 0.001

   Statin

4274 (75)

1295 (75)

906 (64)

667 (64)‡

< 0.001

< 0.001

   ACE inhibitor

4191 (74)

1294 (75)

891 (63)

629 (60)‡

< 0.001

< 0.001

   ARB

656 (12)

249 (14)¶

235 (17)

213 (21)‡§

< 0.001

< 0.001

  1. Data are presented as mean ± SD or number of patients (percentage). Not normally distributed variables were described as median (25th, 75th percentile). Group I, estimated GFR ≥ 60(ml/min/1.73 m2) without DM; Group II, estimated GFR ≥ 60 with DM; Group III, estimated GFR < 60 without DM; Group IV, estimated GFR < 60 with DM.
  2. Abbreviations: HR, heart rate; CAD, coronary arterial disease; LDL-C, low-density lipoprotein cholesterol; NT-proBNP, N-terminal pro-brain natriuretic peptide; hs-CRP, high-sensitivity C-Reactive Protein; LVEF, left ventricular ejection fraction; STEMI, ST-segment elevation acute myocardial infarction; GFR, Glomerular filtration rate; CCB, calcium channel blocker; ACE, angiotensin converting enzyme; ARB, angiotensin II receptor blockers.
  3. *On the basis of abbreviated MDRD (Modification of Diet in Renal Disease) study equation.
  4. †Statistical significance for linear-by-linear association between categorical variables calculated using chi-square-test for trend.
  5. ¶ p < 0.05 Compared with Group I.
  6. ‡p < 0.05 Compared with Group II.
  7. § p < 0.05 Compared with Group III.
Back to article page

Cardiovascular Diabetology

ISSN: 1475-2840