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Table 6 Evaluation of insulin sensitivity with the insulin resistance indexes

From: Novel adiponectin-resistin (AR) and insulin resistance (IRAR) indexes are useful integrated diagnostic biomarkers for insulin resistance, type 2 diabetes and metabolic syndrome: a case control study

 

Subjects

 

Insulin

resistance

indexes

Control

(n = 208)

group A

MS

without T2DM

(n = 174)

group B

T2DM

without MS

(n = 171)

group C

T2DM

with MS

(n = 256)

group D

F-test; P-value

(A vs. B vs. C vs. D)

HOMA-IR index

2.546 (2.317, 2.779) )

5.038 (4.334, 5.923)

5.066 (4.367, 5.968)

8.706 (7.476, 10.183)

26.447; 2.55 × 10-16

 

B***, C***, D***

A***, D***

A***, D***

A***, B***, C***

 

QUICKI

0.346 (0.342, 0.351)

0.317 (0.313, 0.320)

0.319 (0.314, 0.324)

0.296 (0.293, 0.299)

103.892; 7.62 × 10-57

 

B***, C***, D***

A***, D***

A***, D***

A***, B***, C***

 

Bennett index

0.309 (0.293, 0.327)

0.228 (0.220, 0.237)

0.240 (0.224, 0.257)

0.181 (0.175, 0.186)

76.614; 1.38 × 10-43

 

B***, C***, D***

A***, D***

A***, D***

A***, B***, C***

 

McAuley (1) index

7.235 (7.009, 7.474)

5.305 (5.151, 5.475)

7.095 (6.845, 7.375)

5.347 (5.187, 5.518)

105.878; 9.02 × 10-58

 

B***, D***

A***, C***

B***, D***

A***, C***

 

McAuley (2) index

7.447 (7.227, 7.664)

5.496 (5.326, 5.651)

7.331 (7.103, 7.580)

5.486 (5.336, 5.627)

120.944; 1.20 × 10-64

 

B***, D***

A***, C***

B***, D***

A***, C***

 

IRAR index

3.401 (3.265, 3.538)

4.132 (3.955, 4.305)

4.604 (4.403, 4.791)

5.455 (5.305, 5.612)

117.190; 5.84 × 10-63

 

B***, C***, D***

A***, C**, D***

A***, B**, D***

A***, B***, C***

 
  1. Data are expressed as mean (95% confident interval). ANCOVA test was used, followed by pairwise comparison using 1,000 stratified bootstrap samples with bias corrected and accelerated (BCa) 95% CI for multiple testing bias corrections due to deviation of normality. The p-value was also adjusted for covariate ages with stratified ethnicity. The location of statistically significant differences are displayed as group's name (A, B, C, or D). Significant levels: P* < 0.05, P** < 0.01, P*** < 0.001. Note: T2DM = type 2 diabetes; MS = metabolic syndrome; HOMA-IR = homeostasis model assessment of insulin resistance; QUICKI = quantitative insulin sensitivity check index, IRAR = insulin resistance (adiponectin-resistin).
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Cardiovascular Diabetology

ISSN: 1475-2840