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Table 1 Clinical characteristics in 200 type 2 diabetic patients and in 173 patients with or without atherosclerosis, including coronary calcium score (CCS) ≥400, ankle-brachial index (ABI) < 0.90 and/or toe-brachial index (TBI) < 0.64 and/or carotis intima-media thickness (CIMT) > 0.90 mm, respectively

From: NT-proBNP levels, atherosclerosis and vascular function in asymptomatic type 2 diabetic patients with microalbuminuria: peripheral reactive hyperaemia index but not NT-proBNP is an independent predictor of coronary atherosclerosis

 

All patients (n = 200)

Patients with atherosclerosis (n = 85) ^

Patients without atherosclerosis (n = 88) ^

p-values

Sex no. (male%)

152 (76)

73 (86)

59 (67)

0.004

Age (years)

59 (9)

62 (5)

55 (9)

<0.001

Duration of diabetes (years)

13 (7)

14 (7)

11 (7)

0.001

BMI (kg/m2)

32.6 (5.8)

31.5 (5.3)

33.5 (6.2)

0.029

HbA1c (%)

7.9 (1.3)

7.8 (1.2)

7.9 (1.5)

0.62

Urinary albumin excretion rate (mg/24h)*

103 (39 - 230)

98 (33-293)

87 (44-191)

0.85

P-creatinine (μmol/l)

76 (18)

79 (18)

74 (18)

0.13

Systolic blood pressure (mmHg)

130 (17)

132 (18)

128 (16)

0.16

Total cholesterol (mmol/l)

3.9 (0.9)

3.9 (1.0)

4.0 (0.9)

0.58

Heart rate variation during deep breathing (bpm)*

7 (4.5-11.5)

6 (4-9)

8 (5-13)

0.013

Current smoker no. (%)

59 (30)

31 (36)

19 (22)

0.031

Vibratory perception threshold mV - mean of both sides

33 (15)

36 (14)

30 (15)

0.004

Retinopathy no. (%)

120 (60)

57 (67)

41 (48)

0.010

Abnormal heart rate variation during deep breathing no. (%)

118 (59)

61 (72)

51 (58)

0.015

Ortostatic hypotension no. (%)

15 (7.5)

8 (9)

6 (7)

0.055

Oral antidiabetic medication no. (%)

170 (85)

70 (82)

76 (86)

0.47

Insulin treatment no. (%)

124 (62)

56 (67)

51 (58)

0.28

RAAS blockade no. (%)

196 (98)

82 (96)

87 (99)

0.30

Statin therapy no. (%)

189 (95)

78 (92)

85 (97)

0.20

Aspirin therapy no. (%)

183 (92)

79 (93)

82 (93)

0.95

Beta-blocker therapy no. (%)

27 (14)

14 (16)

11 (13)

0.46

Calcium channel blockers no. (%)

80 (40)

36 (41)

30 (35)

0.26

Use of diuretics no. (%)

128 (64)

58 (66)

53 (62)

0.27

NT-proBNP (ng/l) *

48.7 (18.6-95.0)

44.2 (24.5-108.5)

31.9 (12.7-95.0)

0.021

NT-proBNP > 45.2 (ng/l) no. (%)

104 (52)

49 (58)

40 (45)

0.11

NT-proBNP ≤ 45.2 (ng/l) no. (%)

96 (48)

36 (42)

48 (55)

0.11

  1. Data are expressed as means (SD) or medians (interquartile range) *, nr = not relevant, aOur plasma NT-proBNP (45.2 ng/l) cut-off has previously been described [8],. ^ In five, seven and 17 patients CCS, peripheral systolic blood pressure and CIMT were not measured respectively, and we only included patients with structural tests in all three territories (173/200).
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Cardiovascular Diabetology

ISSN: 1475-2840