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Table 2 Dobutamine stress induced changes in echocardiographic parameters.

From: Left ventricular dysfunction with reduced functional cardiac reserve in diabetic and non-diabetic LDL-receptor deficient apolipoprotein B100-only mice

% C57Bl/6J LDLR-/-ApoB100/100 IGF-II/LDLR-/-ApoB100/100
ΔHR 13.22 ± 8.45 (0.043) 6.19 ± 6.52 (0.070) 9.86 ± 4.93 (0.011)
ΔEF 14.87 ± 4.51 (0.001) 16.83 ± 1.52 (< 0.0001) 16.79 ± 8.53 (0.001)
ΔFS 15.48 ± 6.00 (0.005) 11.91 ± 2.18 (0.003) 13.74 ± 7.44 (0.0145)
ΔLVIDED -9.4 ± 4.5 (0.009) -12.7 ± 6.7 (0.016) -9.3 ± 3.7 (0.032)
ΔLVIDES -31.9 ± 11.1 (0.002) -24.6 ± 6.8 (0.001) -24.9 ± 13.0 (0.017)
ΔLVPW;d 18.0 ± 2.9 (0.099) 19.6 ± 8.4 (0.006) 18.5 ± 11.3 (0.021)
ΔLVPW;s 37.4 ± 19.1 (0.184) 29.7 ± 7.9 (0.0004) 28.3 ± 13.9 (0.004)
ΔLVAW;d 26.7 ± 22.0 (0.863) 23.0 ± 25.7 (0.078) 28.0 ± 12.0 (0.005)
ΔLVAW;s 32.3 ± 10.9 (0.001) 26.6 ± 15.6 (0.010) 28.0 ± 16.6 (0.004)
ΔLV Vol;d -20.5 ± 9.6 (0.009) -25.5 ± 14.1 (0.012) -20.7 ± 7.6 (0.006)
ΔLV Vol;s -61.1 ± 16.8 (0.002) -50.0 ± 12.0 (0.002) -51.6 ± 19.2 (0.012)
Values denote mean ± SD. Dobutamine challenge was performed to 5 (LDLR-/-ApoB100/100 and IGF-II/LDLR-/-ApoB100/100) or 6 mice (C57Bl/6J) per strain. P-values from paired t-test comparing group baseline and the maximal response after dobutamine are shown in parenthesis.