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Table 2 Dobutamine stress induced changes in echocardiographic parameters.

From: Left ventricular dysfunction with reduced functional cardiac reserve in diabetic and non-diabetic LDL-receptor deficient apolipoprotein B100-only mice

%

C57Bl/6J

LDLR-/-ApoB100/100

IGF-II/LDLR-/-ApoB100/100

ΔHR

13.22 ± 8.45 (0.043)

6.19 ± 6.52 (0.070)

9.86 ± 4.93 (0.011)

ΔEF

14.87 ± 4.51 (0.001)

16.83 ± 1.52 (< 0.0001)

16.79 ± 8.53 (0.001)

ΔFS

15.48 ± 6.00 (0.005)

11.91 ± 2.18 (0.003)

13.74 ± 7.44 (0.0145)

ΔLVIDED

-9.4 ± 4.5 (0.009)

-12.7 ± 6.7 (0.016)

-9.3 ± 3.7 (0.032)

ΔLVIDES

-31.9 ± 11.1 (0.002)

-24.6 ± 6.8 (0.001)

-24.9 ± 13.0 (0.017)

ΔLVPW;d

18.0 ± 2.9 (0.099)

19.6 ± 8.4 (0.006)

18.5 ± 11.3 (0.021)

ΔLVPW;s

37.4 ± 19.1 (0.184)

29.7 ± 7.9 (0.0004)

28.3 ± 13.9 (0.004)

ΔLVAW;d

26.7 ± 22.0 (0.863)

23.0 ± 25.7 (0.078)

28.0 ± 12.0 (0.005)

ΔLVAW;s

32.3 ± 10.9 (0.001)

26.6 ± 15.6 (0.010)

28.0 ± 16.6 (0.004)

ΔLV Vol;d

-20.5 ± 9.6 (0.009)

-25.5 ± 14.1 (0.012)

-20.7 ± 7.6 (0.006)

ΔLV Vol;s

-61.1 ± 16.8 (0.002)

-50.0 ± 12.0 (0.002)

-51.6 ± 19.2 (0.012)

Values denote mean ± SD. Dobutamine challenge was performed to 5 (LDLR-/-ApoB100/100 and IGF-II/LDLR-/-ApoB100/100) or 6 mice (C57Bl/6J) per strain. P-values from paired t-test comparing group baseline and the maximal response after dobutamine are shown in parenthesis.