Analysis of coronary artery atherosclerosis and remodeling. A) The degree of luminal stenosis in coronary arteries and B) average absolute vessel (white bars) and respective lesion areas (black bars) in the left coronary artery of 18-month-old mice (mean ± SD). In comparison to C57Bl/6J controls (n = 9), compensatory enlargement of the left coronary artery is seen in LDLR-/-ApoB100/100 (n = 7) and IGF-II/LDLR-/-ApoB100/100 mice (n = 7) with vascular remodeling ratios in parenthesis indicating positive remodeling (> 1.05) in response to atherosclerosis. * P < 0.05 versus C57Bl/6J. C) Representative hematoxylin-eosin stained sections showing severe stenosis in proximal left coronary artery in LDLR-/-ApoB100/100 (middle) and IGF-II/LDLR-/-ApoB100/100 mice (right panel). Original magnification × 200, scale bar 25 μm.