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Table 4 Association between MTNR1B polymorphisms and quantitative traits in non-diabetic controls

From: A common polymorphism rs3781637 in MTNR1B is associated with type 2 diabetes and lipids levels in Han Chinese individuals

rs10830963
Genotype CC CG GG β add ± SEM a P add a * β dom ± SEM b P dom b * β rec ± SEM c P rec c *
n 396 578 164       
Fasting glucose (mmol/l) 4.86 ± 0.02 4.87 ± 0.02 4.84 ± 0.03 -0.009 ± 0.017 0.59 0.0004 ± 0.024 0.99 -0.033 ± 0.032 0.30
Triglyceride (mmol/l) 1.40(1.10-1.90) 1.40(1.00-1.90) 1.40(1.10-1.80) -0.062 ± 0.049 0.21 -0.079 ± 0.070 0.25 -0.080 ± 0.094 0.40
Total cholesterol (mmol/l) 5.20(4.50-5.90) 5.10(4.50-5.73) 5.10(4.50-5.80) -0.015 ± 0.045 0.74 -0.042 ± 0.063 0.50 0.022 ± 0.084 0.79
LDL-C (mmol/l) 3.10(2.54-3.64) 3.09(2.50-3.57) 3.09(2.57-3.67) -0.002 ± 0.039 0.97 -0.020 ± 0.055 0.72 0.030 ± 0.075 0.69
HDL-C (mmol/l) 1.30(1.10-1.60) 1.40(1.13-1.53) 1.40(1.14-1.50) -0.003 ± 0.014 0.84 -0.011 ± 0.019 0.57 0.010 ± 0.026 0.70
rs3781637
Genotype AA AG GG β add ± SEM a P add a * β dom ± SEM b P dom b * β rec ± SEM c P rec c *
n 841 288 14       
Fasting glucose (mmol/l) 4.87 ± 0.01 4.84 ± 0.02 4.78 ± 0.10 -0.037 ± 0.025 0.14 -0.035 ± 0.026 0.18 -0.129 ± 0.124 0.30
Triglyceride (mmol/l) 1.40(1.00-1.90) 1.40(1.00-1.90) 1.70(1.13-2.18) 0.032 ± 0.071 0.65 0.002 ± 0.075 0.98 0.742 ± 0.314 0.018
Total cholesterol (mmol/l) 5.10(4.50-5.80) 5.10(4.40-5.80) 5.60(5.40-6.38) -0.022 ± 0.065 0.74 -0.062 ± 0.069 0.367 0.841 ± 0.316 0.008
LDL-C (mmol/l) 3.07(2.55-3.62) 3.02(2.50-3.56) 3.36(2.81-4.26) -0.021 ± 0.057 0.71 -0.050 ± 0.060 0.40 0.585 ± 0.281 0.038
HDL-C (mmol/l) 1.30(1.13-1.53) 1.30(1.11-1.60) 1.38(1.17-1.59) -0.001 ± 0.020 0.95 0.003 ± 0.021 0.89 -0.086 ± 0.095 0.36
rs1562444
Genotype AA AG GG β add ± SEM a P add a * β dom ± SEM b P dom b * β rec ± SEM c P rec c *
n 520 518 100       
Fasting glucose (mmol/l) 4.86 ± 0.02 4.86 ± 0.02 4.87 ± 0.04 0.005 ± 0.018 0.79 0.005 ± 0.023 0.83 0.009 ± 0.042 0.83
Triglyceride (mmol/l) 1.40(1.00-1.90) 1.40(1.00-1.90) 1.40(0.90-1.90) 0.009 ± 0.047 0.85 0.046 ± 0.060 0.44 -0.108 ± 0.109 0.32
Total cholesterol (mmol/l) 5.10(4.50-5.80) 5.10(4.50-5.80) 5.10(4.40-5.90) -0.004 ± 0.047 0.94 -0.019 ± 0.060 0.75 0.046 ± 0.110 0.67
LDL-C (mmol/l) 3.11(2.57-3.64) 3.03(2.50-3.60) 3.00(2.59-3.58) -0.022 ± 0.042 0.60 -0.041 ± 0.053 0.44 0.020 ± 0.097 0.84
HDL-C (mmol/l) 1.30(1.13-1.51) 1.30(1.11-1.54) 1.36(1.16-1.65) 0.010 ± 0.014 0.51 0.001 ± 0.018 0.97 0.049 ± 0.033 0.14
  1. Data are expressed as means ± SEM and median (interquartile range)
  2. a Calculated using multivariate linear regression, assuming an additive model adjusted for age, sex and BMI
  3. b Calculated using multivariate linear regression, assuming a dominant model adjusted for age, sex and BMI
  4. c Calculated using multivariate linear regression, assuming a recessive model adjusted for age, sex and BMI
  5. * P values shown are not corrected for multiple comparison
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Cardiovascular Diabetology

ISSN: 1475-2840