Table 4 Association between MTNR1B polymorphisms and quantitative traits in non-diabetic controls

Genotype

CC

CG

GG

β _add ± SEM ^a

P _add ^a *

β _dom ± SEM ^b

P _dom ^b *

β _rec ± SEM ^c

P _rec ^c *

n

396

578

164

Fasting glucose (mmol/l)

4.86 ± 0.02

4.87 ± 0.02

4.84 ± 0.03

-0.009 ± 0.017

0.59

0.0004 ± 0.024

0.99

-0.033 ± 0.032

0.30

Triglyceride (mmol/l)

1.40(1.10-1.90)

1.40(1.00-1.90)

1.40(1.10-1.80)

-0.062 ± 0.049

0.21

-0.079 ± 0.070

0.25

-0.080 ± 0.094

0.40

Total cholesterol (mmol/l)

5.20(4.50-5.90)

5.10(4.50-5.73)

5.10(4.50-5.80)

-0.015 ± 0.045

0.74

-0.042 ± 0.063

0.50

0.022 ± 0.084

0.79

LDL-C (mmol/l)

3.10(2.54-3.64)

3.09(2.50-3.57)

3.09(2.57-3.67)

-0.002 ± 0.039

0.97

-0.020 ± 0.055

0.72

0.030 ± 0.075

0.69

HDL-C (mmol/l)

1.30(1.10-1.60)

1.40(1.13-1.53)

1.40(1.14-1.50)

-0.003 ± 0.014

0.84

-0.011 ± 0.019

0.57

0.010 ± 0.026

0.70

rs3781637

Genotype

AA

AG

GG

β _add ± SEM ^a

P _add ^a *

β _dom ± SEM ^b

P _dom ^b *

β _rec ± SEM ^c

P _rec ^c *

n

841

288

14

Fasting glucose (mmol/l)

4.87 ± 0.01

4.84 ± 0.02

4.78 ± 0.10

-0.037 ± 0.025

0.14

-0.035 ± 0.026

0.18

-0.129 ± 0.124

0.30

Triglyceride (mmol/l)

1.40(1.00-1.90)

1.40(1.00-1.90)

1.70(1.13-2.18)

0.032 ± 0.071

0.65

0.002 ± 0.075

0.98

0.742 ± 0.314

0.018

Total cholesterol (mmol/l)

5.10(4.50-5.80)

5.10(4.40-5.80)

5.60(5.40-6.38)

-0.022 ± 0.065

0.74

-0.062 ± 0.069

0.367

0.841 ± 0.316

0.008

LDL-C (mmol/l)

3.07(2.55-3.62)

3.02(2.50-3.56)

3.36(2.81-4.26)

-0.021 ± 0.057

0.71

-0.050 ± 0.060

0.40

0.585 ± 0.281

0.038

HDL-C (mmol/l)

1.30(1.13-1.53)

1.30(1.11-1.60)

1.38(1.17-1.59)

-0.001 ± 0.020

0.95

0.003 ± 0.021

0.89

-0.086 ± 0.095

0.36

rs1562444

Genotype

AA

AG

GG

β _add ± SEM ^a

P _add ^a *

β _dom ± SEM ^b

P _dom ^b *

β _rec ± SEM ^c

P _rec ^c *

n

520

518

100

Fasting glucose (mmol/l)

4.86 ± 0.02

4.86 ± 0.02

4.87 ± 0.04

0.005 ± 0.018

0.79

0.005 ± 0.023

0.83

0.009 ± 0.042

0.83

Triglyceride (mmol/l)

1.40(1.00-1.90)

1.40(1.00-1.90)

1.40(0.90-1.90)

0.009 ± 0.047

0.85

0.046 ± 0.060

0.44

-0.108 ± 0.109

0.32

Total cholesterol (mmol/l)

5.10(4.50-5.80)

5.10(4.50-5.80)

5.10(4.40-5.90)

-0.004 ± 0.047

0.94

-0.019 ± 0.060

0.75

0.046 ± 0.110

0.67

LDL-C (mmol/l)

3.11(2.57-3.64)

3.03(2.50-3.60)

3.00(2.59-3.58)

-0.022 ± 0.042

0.60

-0.041 ± 0.053

0.44

0.020 ± 0.097

0.84

HDL-C (mmol/l)

1.30(1.13-1.51)

1.30(1.11-1.54)

1.36(1.16-1.65)

0.010 ± 0.014

0.51

0.001 ± 0.018

0.97

0.049 ± 0.033

0.14