Figure 2

Effect of aspirin on the primary prevention of myocardial infarction (non-fatal and fatal), stroke (non-fatal and fatal), cardiovascular death, major adverse cardiovascular events (a composite of non-fatal myocardial infarction, non-fatal stroke, and cardiovascular death), and all-cause mortality in patients with diabetes. Relative risks (RRs) are indicated by squares with the relative weight of each trial represented by the size of each square. 95% confidence intervals (CIs) are indicated by horizontal lines. Pooled risk estimates and corresponding 95% CIs are represented by diamonds. Squares or diamonds to the left of the solid line indicate benefit with aspirin therapy. JPAD = Japanese Primary Prevention of Atherosclerosis with Aspirin for Diabetes; POPADAD = Prevention Of Progression of Arterial Disease And Diabetes; WHS = Women's Health Study; PPP = Primary Prevention Project; ETDRS = Early Treatment Diabetic Retinopathy Study; HOT = Hypertension Optimal Treatment; and PHS = Physicians' Health Study.