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Table 1 Clinical characteristics of type 2 diabetic patients and non-diabetic subjects

From: The association of dimethylarginine dimethylaminohydrolase 1 gene polymorphism with type 2 diabetes: a cohort study

  Type 2 DM patients n = 309 Non-DM subjects n = 505 P value
Age (years) 65.4 ± 10.4 64.8 ± 10.8 0.57
Gender (Women/men) 74/235 123/382 0.90
BMI (Kg/m2) 27.2 ± 3.9 25.6 ± 3.4 < 0.001
Hypertension (%) 252 (81.0) 348 (68.9) < 0.001
Smoking (%) 64 (20.7) 106 (21.0) 0.93
Hypercholesterolemia (%) 139 (45.1) 228 (45.1) 1.00
Cholesterol (mg/dl)    
Total 164.7 ± 33.4 175.1 ± 37.3 < 0.001
HDL-Cholesterol 40.1 ± 11.1 44.9 ± 12.7 < 0.001
LDL-Cholesterol 99.6 ± 28.4 110.0 ± 33.6 < 0.001
Triglyceride (mg/dl) 155.0 ± 96.8 138.0 ± 85.4 < 0.001
Creatinine (mg/dl) 1.3 ± 1.0 1.1 ± 0.5 < 0.001
eGFR (ml/min per 1.73 m2) 70.8 ± 30.0 80.1 ± 24.9 < 0.001
Fasting blood sugar(mg/dl) 138.0 ± 48.3 92.7 ± 14.5 < 0.001
ADMA (μmol/l) 0.46 ± 0.09 0.45 ± 0.10 0.12
L-arginine (μmol/l) 88.3 ± 29.7 97.3 ± 33.3 < 0.001
L-arginine/ADMA 196.0 ± 67.0 225.0 ± 86.1 < 0.001
Medications    
   Anti-platelet drug 272 (88.0) 420 (83.2) 0.07
   Statins 144 (46.4) 201 (39.8) 0.06
   ACE-Inhibitor/ARB 108 (35.0) 111 (22.0) <0.001
   Calcium channel blocker 69 (22.3) 115(22.8) 0.88
   Hypoglycemic treatments    
Insulin (%) 49 (15.8) - -
OHA (%) 244 (79.0) - -
Insulin + OHA (%) 8 (2.6) - -
  1. ACE: angiotensin converting enzyme; ARB: angiotensin receptor blocker. BMI: body mass index; eGFR: estimated glomerular filtration rate; OHA: oral hypoglycemic agents.