Effect of nicorandil on STZ-induced endothelial dysfunction in rats. Ultrasound measurements were performed at 4 weeks after STZ administration. Time courses of velocity (A), FMD (B) and NTG-induced vasodilation (C) in rat femoral arteries were measured after 5-min ischemia. ?% of velocity (D) and NTG-induced vasodilation (F) were similar among groups. FMD peaked at 1 min after reperfusion and then decreased in diabetic rats, showing improvement by nicorandil (E). *p < 0.05 vs normal, #p < 0.05 vs STZ (n = 6-7).