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2022 Editor's Highlights

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Another successful year for Cardiovascular Diabetology comes to a close – with an Impact Factor of 8.949, our journal is positioned in the 80.36 and 90.07 percentiles of academic periodicals in the categories "Cardiac & Cardiovascular Systems” and “Endocrinology & Metabolism”, respectively. Thus, remaining the leading open access journal in the latter category. However, the sad passing of Professor Alexander Tenenbaum, co-founder of the journal, clouds our achievements this year. Professor Tenenbaum, a gifted cardiologist and researcher, left us on August 22, after a long and painful illness. 

On the other hand, a positive development for the journal has been the influx of new Associate Editors we have seen this year, of whom with their knowledge and experience, contribute enormously to the success of Cardiovascular Diabetology. 

This year saw a special interest in issues like the prognostic importance of the triglyceride glucose index, machine learning, biomarkers, novel pharmacotherapy for Type 2 Diabetes Mellitus, percutaneous coronary interventions in diabetic patients, dyslipidemia, heart failure, influence of anthropometric measurements on the development of cardiometabolic diseases, coagulation and fibrinolysis, epicardial fat thickness, proteomics, gender-specific differences and epidemiology. 

During 2022, the journal published more articles than ever before - nearly 300, with most of them original manuscripts. Here, we would like to offer you a selection of this year’s highlight articles.


Machine learning of plasma metabolome identifies biomarker panels for metabolic syndrome: findings from the China Suboptimal Health Cohort

Hao Wang, Youxin Wang, Xingang Li, Xuan Deng, Yuanyuan Kong, Wei Wang & Yong Zhou

Research | Published: 23 December 2022


Management of type 2 diabetes with a treat-to-benefit approach improved long-term cardiovascular outcomes under routine care

Mario Luca Morieri, Enrico Longato, Barbara Di Camillo, Giovanni Sparacino, Angelo Avogaro and Gian Paolo Fadini

Research | Published: 9 December 2022


Body mass index versus surrogate measures of central adiposity as independent predictors of mortality in type 2 diabetes 

Emanuela Orsi, Anna Solini, Giuseppe Penno, Enzo Bonora, Cecilia Fondelli, Roberto Trevisan, Monica Vedovato, Franco Cavalot, Olga Lamacchia, Jonida Haxhi, Antonio Nicolucci & Giuseppe Pugliese for the Renal Insufficiency And Cardiovascular Events (RIACE) Study Group

Research | Published: 2 December 2022


Triglyceride-glucose index as a prognostic marker after ischemic stroke or transient ischemic attack: a prospective observational study.

Takao Hoshino, Takafumi Mizuno, Kentaro Ishizuka, Shuntaro Takahashi, Satoko Arai, Sono Toi and Kazuo Kitagawa

Research | Published: 30 November 2022


Personalized management of dyslipidemias in patients with diabetes—it is time for a new approach (2022)

Maciej Banach, Stanisław Surma, Zeljko Reiner, Niki Katsiki, Peter E. Penson, Zlatko Fras, Amirhossein Sahebkar, Francesco Paneni, Manfredi Rizzo and John Kastelein

Review | Published: 28 November 2022


Unsupervised machine learning based on clinical factors for the detection of coronary artery atherosclerosis in type 2 diabetes mellitus

Yu Jiang, Zhi-Gang Yang, Jin Wang, Rui Shi, Pei-Lun Han, Wen-Lei Qian, Wei-Feng Yan and Yuan Li

Research | Published: 28 November 2022


Risk factors for cardiovascular disease in patients with metabolic-associated fatty liver disease: a machine learning approach

Karolina Drożdż, Katarzyna Nabrdalik, Hanna Kwiendacz, Mirela Hendel, Anna Olejarz, Andrzej Tomasik, Wojciech Bartman, Jakub Nalepa, Janusz Gumprecht and Gregory Y. H. Lip

Research | Published: 12 November 2022


NT-ProBNP and mortality across the spectrum of glucose tolerance in the general US population

Stefano Ciardullo, Federico Rea, Rosa Cannistraci, Emanuele Muraca, Silvia Perra, Francesca Zerbini, Andrea Mortara and Gianluca Perseghin

Research | Published: 7 November 2022


The association between macrovascular complications and intensive care admission, invasive mechanical ventilation, and mortality in people with diabetes hospitalized for coronavirus disease-2019 (COVID-19)

Gemma Llauradó, Bogdan Vlacho, Matthieu Wargny, Yue Ruan, Josep Franch-Nadal, Pere Domingo, Pierre Gourdy, Pierre-Jean Saulnier, Samy Hadjadj, Sarah H. Wild, Rustam Rea, Bertrand Cariou, Kamlesh Khunti and Dídac Mauricio

Research | Published: 19 October 2022


TyGIS: improved triglyceride-glucose index for the assessment of insulin sensitivity during pregnancy

Benedetta Salvatori, Tina Linder, Daniel Eppel, Micaela Morettini, Laura Burattini, Christian Göbl and Andrea Tura

Research | Published: 18 October 2022


Plasma mannose as a novel marker of myocardial infarction across different glycaemic states: a case control study

Elena Fortin, Giulia Ferrannini, Beatrice Campi, Linda Mellbin, Anna Norhammar, Per Näsman, Alessandro Saba, Ele Ferrannini and Lars Rydén

Research | Published: 23 September 2022


Proteomics of fibrin amyloid microclots in long COVID/post-acute sequelae of COVID-19 (PASC) shows many entrapped pro-inflammatory molecules that may also contribute to a failed fibrinolytic system  

Arneaux Kruger, Mare Vlok, Simone Turner, Chantelle Venter, Gert Jacobus Laubscher, Douglas B. Kell and Etheresia Pretorius

Research | Published: 21 September 2022


Prognostic value of soluble ST2, high-sensitivity cardiac troponin, and NT-proBNP in type 2 diabetes: a 15-year retrospective study  

Jacopo Sabbatinelli, Angelica Giuliani, Anna Rita Bonfigli, Deborah Ramini, Giulia Matacchione, Carla Campolucci, Artan Ceka, Elena Tortato, Maria Rita Rippo, Antonio Domenico Procopio, Marco Moretti and Fabiola Olivieri

Research | Published: 10 September 2022


Revascularization outcomes in diabetic patients presenting with acute coronary syndrome with non-ST elevation  

Eilon Ram, Enrique Z. Fisman, Alexander Tenenbaum, Zaza Iakobishvili, Yael Peled, Ehud Raanani and Leonid Sternik

Original Investigation | Published: 5 September 2022


Tirzepatide, a dual GIP/GLP-1 receptor co-agonist for the treatment of type 2 diabetes with unmatched effectiveness regrading glycaemic control and body weight reduction  

Michael A. Nauck and David A. D‘Alessio

Review | Published: 1 September 2022


Circulating ceramides and sphingomyelins and the risk of incident cardiovascular disease among people with diabetes: the strong heart study 

Paul N. Jensen, Amanda M. Fretts, Andrew N. Hoofnagle, Barbara McKnight, Barbara V. Howard, Jason G. Umans, Colleen M. Sitlani, David S. Siscovick, Irena B. King, Nona Sotoodehnia and Rozenn N. Lemaitre

Research | Published: 30 August 2022


Development and validation of a model to predict cardiovascular death, nonfatal myocardial infarction, or nonfatal stroke in patients with type 2 diabetes mellitus and established atherosclerotic cardiovascular disease 

Susanna R. Stevens, Matthew W. Segar, Ambarish Pandey, Yuliya Lokhnygina, Jennifer B. Green, Darren K. McGuire, Eberhard Standl, Eric D. Peterson and Rury R. Holman

Research | Published: 27 August 2022


Time-resolved trajectory of glucose lowering medications and cardiovascular outcomes in type 2 diabetes: a recurrent neural network analysis 

Enrico Longato, Barbara Di Camillo, Giovanni Sparacino, Angelo Avogaro and Gian Paolo Fadini

Research | Published: 22 August 2022


Prevalence of symptoms, comorbidities, fibrin amyloid microclots and platelet pathology in individuals with Long COVID/Post-Acute Sequelae of COVID-19 (PASC)  

Etheresia Pretorius, Chantelle Venter, Gert Jacobus Laubscher, Maritha J Kotze, Sunday O. Oladejo, Liam R. Watson, Kanshu Rajaratnam, Bruce W. Watson and Douglas B. Kell

Research | Published: 6 August 2022


Polygenic risk for type 2 diabetes, lifestyle, metabolic health, and cardiovascular disease: a prospective UK Biobank study 

Jae-Seung Yun, Sang-Hyuk Jung, Manu Shivakumar, Brenda Xiao, Amit V. Khera, Hong-Hee Won and Dokyoon kim

Research | Published: 14 July 2022


Mannose-binding lectin does not explain the dismal prognosis after an acute coronary event in dysglycaemic patients. A report from the GAMI cohort 

Sara Meziani, Giulia Ferrannini, Mette Bjerre, Troels K. Hansen, Viveca Ritsinger, Anna Norhammar, Viveca Gyberg, Per Näsman, Lars Rydén & Linda G. Mellbin

Research | Published: 8 July 2022


A novel 6-metabolite signature for prediction of clinical outcomes in type 2 diabetic patients undergoing percutaneous coronary intervention

B Xue-bin Wang, Ning-hua Cui and Xia’nan Liu

Research | Published: 4 July 2022


Galectin-4 levels in hospitalized versus non-hospitalized subjects with obesity: the Malmö Preventive Project 

Johan Korduner, Hannes Holm, Amra Jujic, Olle Melander, Manan Pareek, John Molvin, Lennart Råstam, Ulf Lindblad, Bledar Daka, Margret Leosdottir, Peter M. Nilsson, Erasmus Bachus, Michael H. Olsen and Martin Magnusson

Research | Published: 2 July 2022


Epidemiology of the diabetes-cardio-renal spectrum: a cross-sectional report of 1.4 million adults 

Meir Schechter, Cheli Melzer Cohen, Ilan Yanuv, Aliza Rozenberg, Gabriel Chodick, Johan Bodegård, Lawrence A. Leiter, Subodh Verma, Hiddo J. Lambers Heerspink, Avraham Karasik and Ofri Mosenzon

Research | Published: 10 June 2022


Patients phenotypes and cardiovascular risk in type 2 diabetes: the Jackson Heart Study 

Justin B. Echouffo-Tcheugui, Solomon K. Musani, Alain G. Bertoni, Adolfo Correa, Ervin R. Fox and Robert J. Mentz

Research | Published: 1 June 2022


Hemoglobin A1C as a prognostic factor and the pre-diabetic paradox in patients admitted to a tertiary care medical center intensive cardiac care unit 

Lior Lupu, Louay Taha, Rivka Farkash, Feras Bayya, Mohammad Karmi, Yoed Steinmetz, Fauzi Fadi Shaheen, Nimrod Perel, Kamal Hamayel, Nir Levi, Tommer Maller, Hani Karameh, Gavriel Lichewitz, Dov Gavish, Nurit Algur, Michael Glikson & Elad Asher

Research | Published: 30 May 2022


Alteration of circulating platelet-related and diabetes-related microRNAs in individuals with type 2 diabetes mellitus: a stepwise hypoglycaemic clamp study 

Ceren Eyileten, Zofia Wicik, Disha Keshwani, Faisal Aziz, Felix Aberer, Peter N. Pferschy, Norbert J. Tripolt, Caren Sourij, Barbara Prietl, Florian Prüller, Dirk von Lewinski, Salvatore De Rosa, Jolanta M. Siller-Matula, Marek Postula and Harald Sourij

Research | Published: 20 May 2022


Increased frequency of proangiogenic tunica intima endothelial kinase 2 (Tie2) expressing monocytes in individuals with type 2 diabetes mellitus 

M. Reijrink, J. van Ark, C. P. H. Lexis, L. M. Visser, M. E. Lodewijk, I. C. C. van der Horst, C. J. Zeebregts, H. van Goor, S. C. A. de Jager, G. Pasterkamp, B. H. R. Wolffenbuttel and J. L. Hillebrands

Research | Published: 12 May 2022


Differential prognostic burden of cardiovascular disease and lower-limb amputation on the risk of all-cause death in people with long-standing type 1 diabetes 

Marion Camoin, Gilberto Velho, Pierre-Jean Saulnier, Louis Potier, Yawa Abouleka, Charlyne Carpentier, Severine Dubois, Alice Larroumet, Vincent Rigalleau, Elise Gand, Olivier Bourron, Lyse Bordier, André Scheen, Samy Hadjadj, Ronan Roussel, Michel Marre & Kamel Mohammedi

Research | Published: 9 May 2022


Time trends (2001–2019) and sex differences in incidence and in-hospital mortality after lower extremity amputations among patients with type 1 diabetes in Spain 

Ana Lopez-de-Andres, Rodrigo Jimenez-Garcia, Valentín Hernández-Barrera, Javier de-Miguel-Diez, José M. de-Miguel-Yanes, Ricardo Omaña-Palanco and David Carabantes-Alarcon

Research | Published: 3 May 2022


Serum metabolomic profiles associated with subclinical and clinical cardiovascular phenotypes in people with type 2 diabetes

Zhe Huang, Lucija Klaric, Justina Krasauskaite, Stela McLachlan, Mark W. J. Strachan, James F. Wilson and Jackie F. Price

Research | Published: 27 April 2022


Heterogeneous treatment effects of intensive glycemic control on major adverse cardiovascular events in the ACCORD and VADT trials: a machine-learning analysis 

Justin A. Edward, Kevin Josey, Gideon Bahn, Liron Caplan, Jane E. B. Reusch, Peter Reaven, Debashis Ghosh and Sridharan Raghavan

Research | Published: 27 April 2022


Report from the CVOT Summit 2021: new cardiovascular, renal, and glycemic outcomes 

Oliver Schnell, Tadej Battelino, Richard Bergenstal, Matthias Blüher, Michael Böhm, Frank Brosius, Richard D. Carr, Antonio Ceriello, Thomas Forst, Francesco Giorgino, Bruno Guerci, Hiddo J. L. Heerspink, Baruch Itzhak, Linong Ji, Mikhail Kosiborod, Nebojša Lalić, Michael Lehrke, Nikolaus Marx, Michael Nauck, Helena W. Rodbard, Giuseppe M. C. Rosano, Peter Rossing, Lars Rydén, Francesca Santilli, Petra-Maria Schumm-Draeger, Per Olav Vandvik, Tina Vilsbøll, Christoph Wanner, Carol Wysham & Eberhard Standl

Commentary | Published: 8 April 2022


High pericoronary adipose tissue attenuation on computed tomography angiography predicts cardiovascular events in patients with type 2 diabetes mellitus: post-hoc analysis from a prospective cohort study 

Keishi Ichikawa, Toru Miyoshi, Kazuhiro Osawa, Mitsutaka Nakashima, Takashi Miki, Takahiro Nishihara, Hironobu Toda, Masatoki Yoshida and Hiroshi Ito

Original investigation | Published: 18 March 2022


Sex-specific associations of fat mass and muscle mass with cardiovascular disease risk factors in adults with type 2 diabetes living with overweight and obesity: secondary analysis of the Look AHEAD trial 

Tasuku Terada, Jennifer L. Reed, Sol Vidal-Almela, Matheus Mistura, Kentaro Kamiya and Kimberley L. Way

Original investigation | Published: 15 March 2022


The effect of empagliflozin on growth differentiation factor 15 in patients with heart failure: a randomized controlled trial (Empire HF Biomarker) 

Massar Omar, Jesper Jensen, Caroline Kistorp, Kurt Højlund, Lars Videbæk, Christian Tuxen, Julie H. Larsen, Camilla F. Andersen, Finn Gustafsson, Lars Køber, Morten Schou and Jacob Eifer Møller

Original investigation | Published: 27 February 2022


Angiogenic content of microparticles in patients with diabetes and coronary artery disease predicts networks of endothelial dysfunction 

Isra Marei, Omar Chidiac, Binitha Thomas, Jennifer Pasquier, Soha Dargham, Amal Robay, Muneera Vakayil, Mohammad Jameesh, Christopher Triggle, Arash Rafii, Amin Jayyousi, Jassim Al Suwaidi and Charbel Abi Khalil

Original investigation | Published: 2 February 2022


HbA1c variability predicts cardiovascular complications in type 2 diabetes regardless of being at glycemic target 

Antonio Ceriello, Giuseppe Lucisano, Francesco Prattichizzo, Rosalba La Grotta, Stefan Franzén, Ann-Marie Svensson, Björn Eliasson and Antonio Nicolucci

Original investigation | Published: 24 January 2022


Fetuin-A and risk of diabetes-related vascular complications: a prospective study

Anna Birukov, Elli Polemiti, Susanne Jäger, Norbert Stefan and Matthias B. Schulze

Original investigation | Published: 8 January 2022

Cardiovascular Diabetology is affiliated with Sackler Faculty of Medicine, Tel-Aviv University

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