2022 Editor's Highlights

Another successful year for Cardiovascular Diabetology comes to a close – with an Impact Factor of 8.949, our journal is positioned in the 80.36 and 90.07 percentiles of academic periodicals in the categories "Cardiac & Cardiovascular Systems” and “Endocrinology & Metabolism”, respectively. Thus, remaining the leading open access journal in the latter category. However, the sad passing of Professor Alexander Tenenbaum, co-founder of the journal, clouds our achievements this year. Professor Tenenbaum, a gifted cardiologist and researcher, left us on August 22, after a long and painful illness. 

On the other hand, a positive development for the journal has been the influx of new Associate Editors we have seen this year, of whom with their knowledge and experience, contribute enormously to the success of Cardiovascular Diabetology. 

This year saw a special interest in issues like the prognostic importance of the triglyceride glucose index, machine learning, biomarkers, novel pharmacotherapy for Type 2 Diabetes Mellitus, percutaneous coronary interventions in diabetic patients, dyslipidemia, heart failure, influence of anthropometric measurements on the development of cardiometabolic diseases, coagulation and fibrinolysis, epicardial fat thickness, proteomics, gender-specific differences and epidemiology. 

During 2022, the journal published more articles than ever before - nearly 300, with most of them original manuscripts. Here, we would like to offer you a selection of this year’s highlight articles.

Machine learning of plasma metabolome identifies biomarker panels for metabolic syndrome: findings from the China Suboptimal Health Cohort

_{Hao Wang, Youxin Wang, Xingang Li, Xuan Deng, Yuanyuan Kong, Wei Wang & Yong Zhou}

_{Research | Published: 23 December 2022}

Management of type 2 diabetes with a treat-to-benefit approach improved long-term cardiovascular outcomes under routine care

_{Mario Luca Morieri, Enrico Longato, Barbara Di Camillo, Giovanni Sparacino, Angelo Avogaro and Gian Paolo Fadini}

_{Research | Published: 9 December 2022}

Body mass index versus surrogate measures of central adiposity as independent predictors of mortality in type 2 diabetes 

_{Emanuela Orsi, Anna Solini, Giuseppe Penno, Enzo Bonora, Cecilia Fondelli, Roberto Trevisan, Monica Vedovato, Franco Cavalot, Olga Lamacchia, Jonida Haxhi, Antonio Nicolucci & Giuseppe Pugliese for the Renal Insufficiency And Cardiovascular Events (RIACE) Study Group}

_{Research | Published: 2 December 2022}

Triglyceride-glucose index as a prognostic marker after ischemic stroke or transient ischemic attack: a prospective observational study.

_{Takao Hoshino, Takafumi Mizuno, Kentaro Ishizuka, Shuntaro Takahashi, Satoko Arai, Sono Toi and Kazuo Kitagawa}

_{Research | Published: 30 November 2022}

Personalized management of dyslipidemias in patients with diabetes—it is time for a new approach (2022)

_{Maciej Banach, Stanisław Surma, Zeljko Reiner, Niki Katsiki, Peter E. Penson, Zlatko Fras, Amirhossein Sahebkar, Francesco Paneni, Manfredi Rizzo and John Kastelein}

_{Review | Published: 28 November 2022}

Unsupervised machine learning based on clinical factors for the detection of coronary artery atherosclerosis in type 2 diabetes mellitus

_{Yu Jiang, Zhi-Gang Yang, Jin Wang, Rui Shi, Pei-Lun Han, Wen-Lei Qian, Wei-Feng Yan and Yuan Li}

_{Research | Published: 28 November 2022}

Risk factors for cardiovascular disease in patients with metabolic-associated fatty liver disease: a machine learning approach

_{Karolina Drożdż, Katarzyna Nabrdalik, Hanna Kwiendacz, Mirela Hendel, Anna Olejarz, Andrzej Tomasik, Wojciech Bartman, Jakub Nalepa, Janusz Gumprecht and Gregory Y. H. Lip}

_{Research | Published: 12 November 2022}

NT-ProBNP and mortality across the spectrum of glucose tolerance in the general US population

_{Stefano Ciardullo, Federico Rea, Rosa Cannistraci, Emanuele Muraca, Silvia Perra, Francesca Zerbini, Andrea Mortara and Gianluca Perseghin}

_{Research | Published: 7 November 2022}

The association between macrovascular complications and intensive care admission, invasive mechanical ventilation, and mortality in people with diabetes hospitalized for coronavirus disease-2019 (COVID-19)

_{Gemma Llauradó, Bogdan Vlacho, Matthieu Wargny, Yue Ruan, Josep Franch-Nadal, Pere Domingo, Pierre Gourdy, Pierre-Jean Saulnier, Samy Hadjadj, Sarah H. Wild, Rustam Rea, Bertrand Cariou, Kamlesh Khunti and Dídac Mauricio}

_{Research | Published: 19 October 2022}

TyGIS: improved triglyceride-glucose index for the assessment of insulin sensitivity during pregnancy

_{Benedetta Salvatori, Tina Linder, Daniel Eppel, Micaela Morettini, Laura Burattini, Christian Göbl and Andrea Tura}

_{Research | Published: 18 October 2022}

Plasma mannose as a novel marker of myocardial infarction across different glycaemic states: a case control study

_{Elena Fortin, Giulia Ferrannini, Beatrice Campi, Linda Mellbin, Anna Norhammar, Per Näsman, Alessandro Saba, Ele Ferrannini and Lars Rydén}

_{Research | Published: 23 September 2022}

Proteomics of fibrin amyloid microclots in long COVID/post-acute sequelae of COVID-19 (PASC) shows many entrapped pro-inflammatory molecules that may also contribute to a failed fibrinolytic system  

_{Arneaux Kruger, Mare Vlok, Simone Turner, Chantelle Venter, Gert Jacobus Laubscher, Douglas B. Kell and Etheresia Pretorius}

_{Research | Published: 21 September 2022}

Prognostic value of soluble ST2, high-sensitivity cardiac troponin, and NT-proBNP in type 2 diabetes: a 15-year retrospective study  

_{Jacopo Sabbatinelli, Angelica Giuliani, Anna Rita Bonfigli, Deborah Ramini, Giulia Matacchione, Carla Campolucci, Artan Ceka, Elena Tortato, Maria Rita Rippo, Antonio Domenico Procopio, Marco Moretti and Fabiola Olivieri}

_{Research | Published: 10 September 2022}

Revascularization outcomes in diabetic patients presenting with acute coronary syndrome with non-ST elevation  

_{Eilon Ram, Enrique Z. Fisman, Alexander Tenenbaum, Zaza Iakobishvili, Yael Peled, Ehud Raanani and Leonid Sternik}

_{Original Investigation | Published: 5 September 2022}

Tirzepatide, a dual GIP/GLP-1 receptor co-agonist for the treatment of type 2 diabetes with unmatched effectiveness regrading glycaemic control and body weight reduction  

_{Michael A. Nauck and David A. D‘Alessio}

_{Review | Published: 1 September 2022}

Circulating ceramides and sphingomyelins and the risk of incident cardiovascular disease among people with diabetes: the strong heart study 

_{Paul N. Jensen, Amanda M. Fretts, Andrew N. Hoofnagle, Barbara McKnight, Barbara V. Howard, Jason G. Umans, Colleen M. Sitlani, David S. Siscovick, Irena B. King, Nona Sotoodehnia and Rozenn N. Lemaitre}

_{Research | Published: 30 August 2022}

Development and validation of a model to predict cardiovascular death, nonfatal myocardial infarction, or nonfatal stroke in patients with type 2 diabetes mellitus and established atherosclerotic cardiovascular disease 

_{Susanna R. Stevens, Matthew W. Segar, Ambarish Pandey, Yuliya Lokhnygina, Jennifer B. Green, Darren K. McGuire, Eberhard Standl, Eric D. Peterson and Rury R. Holman}

_{Research | Published: 27 August 2022}

Time-resolved trajectory of glucose lowering medications and cardiovascular outcomes in type 2 diabetes: a recurrent neural network analysis 

_{Enrico Longato, Barbara Di Camillo, Giovanni Sparacino, Angelo Avogaro and Gian Paolo Fadini}

_{Research | Published: 22 August 2022}

Prevalence of symptoms, comorbidities, fibrin amyloid microclots and platelet pathology in individuals with Long COVID/Post-Acute Sequelae of COVID-19 (PASC)  

_{Etheresia Pretorius, Chantelle Venter, Gert Jacobus Laubscher, Maritha J Kotze, Sunday O. Oladejo, Liam R. Watson, Kanshu Rajaratnam, Bruce W. Watson and Douglas B. Kell}

_{Research | Published: 6 August 2022}

Polygenic risk for type 2 diabetes, lifestyle, metabolic health, and cardiovascular disease: a prospective UK Biobank study 

_{Jae-Seung Yun, Sang-Hyuk Jung, Manu Shivakumar, Brenda Xiao, Amit V. Khera, Hong-Hee Won and Dokyoon kim}

_{Research | Published: 14 July 2022}

Mannose-binding lectin does not explain the dismal prognosis after an acute coronary event in dysglycaemic patients. A report from the GAMI cohort 

_{Sara Meziani, Giulia Ferrannini, Mette Bjerre, Troels K. Hansen, Viveca Ritsinger, Anna Norhammar, Viveca Gyberg, Per Näsman, Lars Rydén & Linda G. Mellbin}

_{Research | Published: 8 July 2022}

A novel 6-metabolite signature for prediction of clinical outcomes in type 2 diabetic patients undergoing percutaneous coronary intervention

_{B Xue-bin Wang, Ning-hua Cui and Xia’nan Liu}

_{Research | Published: 4 July 2022}

Galectin-4 levels in hospitalized versus non-hospitalized subjects with obesity: the Malmö Preventive Project 

_{Johan Korduner, Hannes Holm, Amra Jujic, Olle Melander, Manan Pareek, John Molvin, Lennart Råstam, Ulf Lindblad, Bledar Daka, Margret Leosdottir, Peter M. Nilsson, Erasmus Bachus, Michael H. Olsen and Martin Magnusson}

_{Research | Published: 2 July 2022}

Epidemiology of the diabetes-cardio-renal spectrum: a cross-sectional report of 1.4 million adults 

_{Meir Schechter, Cheli Melzer Cohen, Ilan Yanuv, Aliza Rozenberg, Gabriel Chodick, Johan Bodegård, Lawrence A. Leiter, Subodh Verma, Hiddo J. Lambers Heerspink, Avraham Karasik and Ofri Mosenzon}

_{Research | Published: 10 June 2022}

Patients phenotypes and cardiovascular risk in type 2 diabetes: the Jackson Heart Study 

_{Justin B. Echouffo-Tcheugui, Solomon K. Musani, Alain G. Bertoni, Adolfo Correa, Ervin R. Fox and Robert J. Mentz}

_{Research | Published: 1 June 2022}

Hemoglobin A1C as a prognostic factor and the pre-diabetic paradox in patients admitted to a tertiary care medical center intensive cardiac care unit 

_{Lior Lupu, Louay Taha, Rivka Farkash, Feras Bayya, Mohammad Karmi, Yoed Steinmetz, Fauzi Fadi Shaheen, Nimrod Perel, Kamal Hamayel, Nir Levi, Tommer Maller, Hani Karameh, Gavriel Lichewitz, Dov Gavish, Nurit Algur, Michael Glikson & Elad Asher}

_{Research | Published: 30 May 2022}

Alteration of circulating platelet-related and diabetes-related microRNAs in individuals with type 2 diabetes mellitus: a stepwise hypoglycaemic clamp study 

_{Ceren Eyileten, Zofia Wicik, Disha Keshwani, Faisal Aziz, Felix Aberer, Peter N. Pferschy, Norbert J. Tripolt, Caren Sourij, Barbara Prietl, Florian Prüller, Dirk von Lewinski, Salvatore De Rosa, Jolanta M. Siller-Matula, Marek Postula and Harald Sourij}

_{Research | Published: 20 May 2022}

Increased frequency of proangiogenic tunica intima endothelial kinase 2 (Tie2) expressing monocytes in individuals with type 2 diabetes mellitus 

_{M. Reijrink, J. van Ark, C. P. H. Lexis, L. M. Visser, M. E. Lodewijk, I. C. C. van der Horst, C. J. Zeebregts, H. van Goor, S. C. A. de Jager, G. Pasterkamp, B. H. R. Wolffenbuttel and J. L. Hillebrands}

_{Research | Published: 12 May 2022}

Differential prognostic burden of cardiovascular disease and lower-limb amputation on the risk of all-cause death in people with long-standing type 1 diabetes 

_{Marion Camoin, Gilberto Velho, Pierre-Jean Saulnier, Louis Potier, Yawa Abouleka, Charlyne Carpentier, Severine Dubois, Alice Larroumet, Vincent Rigalleau, Elise Gand, Olivier Bourron, Lyse Bordier, André Scheen, Samy Hadjadj, Ronan Roussel, Michel Marre & Kamel Mohammedi}

_{Research | Published: 9 May 2022}

Time trends (2001–2019) and sex differences in incidence and in-hospital mortality after lower extremity amputations among patients with type 1 diabetes in Spain 

_{Ana Lopez-de-Andres, Rodrigo Jimenez-Garcia, Valentín Hernández-Barrera, Javier de-Miguel-Diez, José M. de-Miguel-Yanes, Ricardo Omaña-Palanco and David Carabantes-Alarcon}

_{Research | Published: 3 May 2022}

Serum metabolomic profiles associated with subclinical and clinical cardiovascular phenotypes in people with type 2 diabetes

_{Zhe Huang, Lucija Klaric, Justina Krasauskaite, Stela McLachlan, Mark W. J. Strachan, James F. Wilson and Jackie F. Price}

_{Research | Published: 27 April 2022}

Heterogeneous treatment effects of intensive glycemic control on major adverse cardiovascular events in the ACCORD and VADT trials: a machine-learning analysis 

_{Justin A. Edward, Kevin Josey, Gideon Bahn, Liron Caplan, Jane E. B. Reusch, Peter Reaven, Debashis Ghosh and Sridharan Raghavan}

_{Research | Published: 27 April 2022}

Report from the CVOT Summit 2021: new cardiovascular, renal, and glycemic outcomes 

_{Oliver Schnell, Tadej Battelino, Richard Bergenstal, Matthias Blüher, Michael Böhm, Frank Brosius, Richard D. Carr, Antonio Ceriello, Thomas Forst, Francesco Giorgino, Bruno Guerci, Hiddo J. L. Heerspink, Baruch Itzhak, Linong Ji, Mikhail Kosiborod, Nebojša Lalić, Michael Lehrke, Nikolaus Marx, Michael Nauck, Helena W. Rodbard, Giuseppe M. C. Rosano, Peter Rossing, Lars Rydén, Francesca Santilli, Petra-Maria Schumm-Draeger, Per Olav Vandvik, Tina Vilsbøll, Christoph Wanner, Carol Wysham & Eberhard Standl}

_{Commentary | Published: 8 April 2022}

High pericoronary adipose tissue attenuation on computed tomography angiography predicts cardiovascular events in patients with type 2 diabetes mellitus: post-hoc analysis from a prospective cohort study 

_{Keishi Ichikawa, Toru Miyoshi, Kazuhiro Osawa, Mitsutaka Nakashima, Takashi Miki, Takahiro Nishihara, Hironobu Toda, Masatoki Yoshida and Hiroshi Ito}

_{Original investigation | Published: 18 March 2022}

Sex-specific associations of fat mass and muscle mass with cardiovascular disease risk factors in adults with type 2 diabetes living with overweight and obesity: secondary analysis of the Look AHEAD trial 

_{Tasuku Terada, Jennifer L. Reed, Sol Vidal-Almela, Matheus Mistura, Kentaro Kamiya and Kimberley L. Way}

_{Original investigation | Published: 15 March 2022}

The effect of empagliflozin on growth differentiation factor 15 in patients with heart failure: a randomized controlled trial (Empire HF Biomarker) 

_{Massar Omar, Jesper Jensen, Caroline Kistorp, Kurt Højlund, Lars Videbæk, Christian Tuxen, Julie H. Larsen, Camilla F. Andersen, Finn Gustafsson, Lars Køber, Morten Schou and Jacob Eifer Møller}

_{Original investigation | Published: 27 February 2022}

Angiogenic content of microparticles in patients with diabetes and coronary artery disease predicts networks of endothelial dysfunction 

_{Isra Marei, Omar Chidiac, Binitha Thomas, Jennifer Pasquier, Soha Dargham, Amal Robay, Muneera Vakayil, Mohammad Jameesh, Christopher Triggle, Arash Rafii, Amin Jayyousi, Jassim Al Suwaidi and Charbel Abi Khalil}

_{Original investigation | Published: 2 February 2022}

HbA1c variability predicts cardiovascular complications in type 2 diabetes regardless of being at glycemic target 

_{Antonio Ceriello, Giuseppe Lucisano, Francesco Prattichizzo, Rosalba La Grotta, Stefan Franzén, Ann-Marie Svensson, Björn Eliasson and Antonio Nicolucci}

_{Original investigation | Published: 24 January 2022}

Fetuin-A and risk of diabetes-related vascular complications: a prospective study

_{Anna Birukov, Elli Polemiti, Susanne Jäger, Norbert Stefan and Matthias B. Schulze}

_{Original investigation | Published: 8 January 2022}