Fig. 3

Treatment effects of ipragliflozin and sitagliptin on serum lipids. Changes from baseline in serum total cholesterol (TC, mg/dL) (A), high-density lipoprotein cholesterol (HDL-C, mg/dL) (B), low-density lipoprotein cholesterol (LDL-C, mg/dL) (C), and triglycerides (TG, mg/dL) (D) in the ipragliflozin and sitagliptin groups are shown as closed circles with blue lines and closed squares with red lines, respectively. Data are expressed as mean ± 95% confidence interval of the mean. *, P < 0.05; **, P < 0.01; ***, P < 0.001 vs. baseline in each group; †, P < 0.05 for difference at the follow up visit; ‡, P < 0.05 for difference during the overall study period, vs. the sitagliptin group in the mixed-effects model analysis