Fig. 2

Treatment effects of ipragliflozin and sitagliptin on glucose metabolism parameters. Changes from baseline in fasting plasma glucose (FPG, mmol/L) (A), serum insulin (pmol/L) (B), HbA1c (%) (C), and glycoalbumin (GA, %) (D) in the ipragliflozin and sitagliptin groups are shown as closed circles with blue lines and closed squares with red lines, respectively. Data are expressed as mean ± 95% confidence interval of the mean. *, P < 0.05; ***, P < 0.001 vs. baseline in each group in the mixed-effects model analysis. §, P < 0.05 for interaction during the overall study period, vs. the sitagliptin group in the mixed-effects model analysis