Table 4 Univariate and multivariable Cox regression analysis of composite endpoint

T2DM

1.89 (1.39–2.59)

< 0.001

1.61 (1.13–2.33)

0.01

Male

0.95 (0.73–1.26)

0.74

Age

1.01 (1.00–1.02)

0.03

1.00 (0.99–1.01)

0.81

BMI

0.91 (0.87–0.94)

< 0.001

0.96 (0.92–0.99)

0.03

SBP

0.97 (0.96–0.98)

< 0.001

0.99 (0.99–1.00)

0.28

NYHA class

1.87 (1.60–2.19)

< 0.001

1.09 (0.87–1.37)

0.43

Hypertension

0.62 (0.44–0.86)

0.005

1.14 (0.75–1.75)

0.54

Atrial fibrllation

2.17 (1.64–2.86)

< 0.001

1.77 (1.24–2.53)

0.003

LBBB

1.71 (1.24–2.38)

0.001

0.96 (0.63–1.45)

0.84

Smoking

1.21 (0.94–1.57)

0.14

Alcohol

0.98 (0.73–1.29)

0.86

ACEI/ARB/ARNI

0.74 (0.55–1.10)

0.10

β-blockers

0.62 (0.46–0.84)

0.002

0.72 (0.50–1.06)

0.09

MRA

1.66 (1.19–2.33)

0.003

0.78 (0.51–1.19)

0.25

Diuretics

2.37 (1.67–3.35)

< 0.001

0.92 (0.57–1.47)

0.72

Digoxin

2.60 (2.01–3.37)

< 0.001

1.67 (1.20–2.33)

0.005

LVEDV index

1.01 (1.01–1.01)

< 0.001

1.01 (1.01–1.01)

< 0.001

LVEF

0.93 (0.91–0.94)

< 0.001

0.98 (0.96–1.01)

0.22

RVEF

0.96 (0.95–0.97)

< 0.001

0.99 (0.98–1.01)

0.32

LGE

2.33 (1.79–3.03)

< 0.001

1.34 (0.95–1.91)

0.10

ECV

1.11 (1.09–1.13)

< 0.001

1.07 (1.05–1.10)

< 0.001