Skip to main content

Table 2 Decomposition of the total association between BMI and the risk of stroke into direct and indirect associations mediated by the TyG

From: Interacting and joint effects of triglyceride-glucose index (TyG) and body mass index on stroke risk and the mediating role of TyG in middle-aged and older Chinese adults: a nationwide prospective cohort study

Model

Association

Proportion mediated

Indirect HR (95% CI)

Direct HR (95% CI)

Model 1 a

   

BMI < 24.0 kg/m2

1 [Reference]

  

BMI in 24.0–27.9 kg/m2

1.06 (1.01–1.12)

1.67 (1.15–2.41)

10.5%

BMI ≥ 28.0 kg/m2

1.11 (1.01–1.21)

1.14 (1.08–1.22)

55.7%

Model 2 b

   

BMI < 24.0 kg/m2

1 [Reference]

  

BMI in 24.0–27.9 kg/m2

1.06 (1.00–1.12)

1.74 (1.21–2.53)

9.7%

BMI ≥ 28.0 kg/m2

1.11 (1.01–1.21)

1.13 (1.08–1.18)

53.9%

Model 3 c

   

BMI < 24.0 kg/m2

1 [Reference]

  

BMI in 24.0–27.9 kg/m2

1.06 (1.01–1.12)

1.37 (0.94–2.01)

16.3%

BMI ≥ 28.0 kg/m2

1.11 (1.01–1.22)

1.09 (0.62–1.93)

53.8%

  1. BMI, body mass index; CI, confidence interval
  2. a Model 1 was adjusted for age, gender
  3. b Model 2 was adjusted for age, gender, marital status, residence, education level, smoking status, and drinking status
  4. c Model 3 was adjusted as model 2 plus hypertension, diabetes, heart disease, dyslipidaemia, kidney disease, and history of medication use for hypertension, diabetes, and dyslipidaemia
Back to article page

Cardiovascular Diabetology

ISSN: 1475-2840