Fig. 2

The role and mechanism of miR-26 in atherosclerosis. MiR-26 regulates the development of atherosclerosis through multiple mechanisms, including suppressing vascular calcification, EC growth, angiogenesis, and VSMC differentiation, cholesterol uptake, inflammatory response, glucose production, and FA synthesis and oxidation. ABCA1 ATP-binding cassette transporter A1, ACC1 acetyl-CoA-carboxylase 1, ACLY ATP-citrate lyase, ACSL3 Acyl-CoA synthetase long-chain 3, ALDH3A2 aldehyde dehydrogenase 3 family member A2, ALPL alkaline phosphatase, ARL4C ARF-like 7, β-MHC β-myosin heavy chain, BMP2 bone morphogenetic protein 2, CD36 cluster of differentiation 36, CPT1A carnitine palmitoyl-transferase 1A, CTGF connective tissue growth factor, DGAT2 diacylglycerol acyltransferase 2, EHHADH enoyl-CoA hydratase/3-hydroxyacyl-CoA dehydrogenase, FAS fatty acid synthase, FBP1 fructose-1,6-bisphosphatase, GATA4 GATA binding protein 4, G6PC glucose-6-phosphatase, GSK3β glycogen synthase kinase-3β, Gys2 glycogen synthase 2, HMGA1 high mobility group A1, IL-1β interleukin (IL)-1 beta, JAG2 jagged canonical Notch ligand 2, KCNJ₂ potassium inwardly rectifying channel subfamily J member 2, LDLR low-density lipoprotein receptor, LIPC lipase C hepatic type, MALT1 mucosa-associated lymphoid tissue lymphoma translocation protein 1, NF-κB nuclear factor κB, PCK1 carboxykinase, PLCβ1 phospholipase C beta, PYGL glycogen phosphorylase L, RUNX2 runt-related protein 2, SCD1 stearoyl-coenzyme A desaturase 1, SMAD1 mothers against decapentaplegic homolog 1, SREBF1 sterol regulatory element-binding transcription factor 1, TAB3 TGFβ-activated kinase binding protein 3, TCF7L2 transcription factor 7 like 2, TNF-α tumor necrosis factor alpha