Glycemic control and cardiovascular outcomes in patients with diabetes and coronary artery disease according to triglyceride-glucose index: a large-scale cohort study

Table 4 Cox regression analysis of glycemic control status with clinical endpoints

Endpoints	Events (%)		Univariable analysis		Multivariable analysis^c
Endpoints	Controlled	Uncontrolled	HR (95%CI)	P value	HR (95%CI)	P value
CV events^a	133 (3.0)	248 (4.4)	0.67 (0.55–0.83)	< 0.001	0.70 (0.56–0.87)	0.001
MACEs^b	111 (2.5)	217 (3.9)	0.64 (0.51–0.81)	< 0.001	0.67 (0.53–0.85)	< 0.001
CV death	57 (1.3)	100 (1.8)	0.72 (0.52-1.00)	0.047	0.72 (0.51–1.01)	0.057
Nonfatal MI	40 (0.9)	93 (1.7)	0.54 (0.37–0.78)	0.001	0.59 (0.41–0.87)	0.007
Nonfatal stroke	22 (0.5)	32 (0.6)	0.87 (0.50–1.49)	0.608	0.85 (0.49–1.50)	0.583

^aCV events were defined as a composite of CV death, nonfatal MI and nonfatal stroke
^bMACEs were defined as a composite of CV death and nonfatal MI
^cModels adjusted for age, male sex, BMI, ACS presentation, family history of CAD, previous MI, previous revascularization, hypertension, previous stroke, PAD, current smoker, LVEF, serum creatinine, TC, HDL-C, LDL-C, hsCRP, SYNTAX score, CTO lesion, aspirin use, statins use and insulin use
Abbreviations as in Tables 1 and 3

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