Glycemic control and cardiovascular outcomes in patients with diabetes and coronary artery disease according to triglyceride-glucose index: a large-scale cohort study

Table 3 Cox regression analysis of TyG index with clinical endpoints

TyG tertiles	Events (%)	Univariable analysis		Multivariable analysis^c
TyG tertiles	Events (%)	HR (95%CI)	P value	HR (95%CI)	P value
CV events^a	381(3.8)	1.27 (1.09–1.48)	0.002	1.78 (1.35–2.35)	< 0.001
T1	112 (3.4)	Reference	-	Reference	-
T2	121 (3.6)	1.07 (0.83–1.39)	0.585	1.10 (0.84–1.45)	0.474
T3	148 (4.4)	1.32 (1.03–1.69)	0.026	1.40 (1.02–1.94)	0.040
MACEs^b	328 (3.3)	1.29 (1.09–1.52)	0.003	1.93 (1.43–2.60)	< 0.001
T1	94 (2.8)	Reference	-	Reference	-
T2	104 (3.1)	1.10 (0.83–1.45)	0.504	1.15 (0.85–1.54)	0.363
T3	130 (3.9)	1.38 (1.06–1.80)	0.017	1.55 (1.09–2.20)	0.016

^aCV events were defined as a composite of CV death, nonfatal MI and nonfatal stroke
^bMACEs were defined as a composite of CV death and nonfatal MI
^cModels adjusted for age, male sex, BMI, ACS presentation, family history of CAD, previous MI, previous revascularization, hypertension, previous stroke, PAD, current smoker, LVEF, serum creatinine, TC, HDL-C, LDL-C, hsCRP, SYNTAX score, CTO lesion, aspirin use, statins use and insulin use
HR hazard ratio, CI confidence interval, CV cardiovascular, MACE major adverse cardiovascular event, other abbreviations as in Table 1

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