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Table 3 Multivariate Cox regression analysis of the role of AIP in assessing changes in glycemic status in patients with prediabetes

From: Evaluation of the role of atherogenic index of plasma in the reversion from Prediabetes to normoglycemia or progression to Diabetes: a multi-center retrospective cohort study

 

Per 1000

person-years

HR (95%CI)

Non-adjusted Model

Model I

Model II

Model III

Prediabetes to NFG

    

AIP

142

0.65 (0.59, 0.70)

0.75 (0.69, 0.82)

0.82 (0.75, 0.89)

0.89 (0.81, 0.98)

AIP (quartile)

     

Q1

172

Ref

Ref

Ref

Ref

Q2

150

0.88 (0.82, 0.94)

0.94 (0.88, 1.01)

0.98 (0.91, 1.04)

1.01 (0.95, 1.08)

Q3

124

0.75 (0.70, 0.80)

0.83 (0.77, 0.89)

0.87 (0.81, 0.94)

0.92 (0.85, 0.99)

Q4

121

0.71 (0.67, 0.76)

0.80 (0.74, 0.86)

0.85 (0.79, 0.96)

0.91 (0.84, 0.98)

P-trend

 

< 0.0001

< 0.0001

< 0.0001

0.0034

Prediabetes to Diabetes

    

AIP

53

2.07 (1.83, 2.35)

1.88 (1.65, 2.14)

1.67 (1.46, 1.91)

1.42 (1.24, 1.64)

AIP (quartile)

    

Q1

35

Ref

Ref

Ref

Ref

Q2

49

1.42 (1.25, 1.61)

1.32 (1.16, 1.51)

1.28 (1.12, 1.46)

1.19 (1.04, 1.36)

Q3

60

1.80 (1.59, 2.04)

1.64 (1.45, 1.86)

1.55 (1.36, 1.76)

1.40 (1.23, 1.60)

Q4

68

1.96 (1.74, 2.21)

1.78 (1.58, 2.01)

1.63 (1.43, 1.85)

1.42 (1.24, 1.61)

P-trend

 

< 0.0001

< 0.0001

< 0.0001

< 0.0001

  1. Abbreviations: HR: hazard ratios; CI: confidence interval; other abbreviations as in Table 1
  2. Model I adjusted for age, sex
  3. Model II adjusted for age, sex, SBP, LDL-C, ALT, BUN and Cr
  4. Model III adjusted for age, sex, SBP, DBP, LDL-C, ALT, BUN, Cr, BMI, family history of diabetes, smoking status, drinking status
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Cardiovascular Diabetology

ISSN: 1475-2840