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Table 3 CMR-derived semi-quantitative and fully quantitative myocardial perfusion analysis

From: Early left ventricular microvascular dysfunction in diabetic pigs: a longitudinal quantitative myocardial perfusion CMR study

 

Before modelling

(n = 8)

2 months after modelling

(n = 9)

6 months after modelling

(n = 10)

10 months after

Modelling

(n = 8)

16 months after modelling

(n = 7)

P value

Semi-quantitative myocardial perfusion

Upslope at rest (SI/sec)

2.27 ± 0.86

2.64 ± 0.73

3.22 ± 1.67

3.12 ± 1.41

3.84 ± 0.88*§

0.029

Upslope at stress (SI/sec)

3.25 ± 1.05

3.25 ± 1.37

3.89 ± 2.36

3.91 ± 1.65

4.40 ± 1.31

0.377

MaxSI at rest (SI)

37.90 ± 6.94

38.16 ± 8.47

36.25 ± 11.56

40.76 ± 13.53

47.28 ± 6.66‡

0.074

MaxSI at stress (SI)

36.63 ± 6.34

37.81 ± 9.42

32.75 ± 10.52

40.15 ± 15.08

44.43 ± 5.76‡

0.061

PI at rest (%)

9.67 ± 3.40

10.16 ± 1.85

10.19 ± 3.80

12.47 ± 10.10

10.56 ± 2.28

0.947

PI at stress (%)

10.58 ± 2.79

10.92 ± 2.25

11.58 ± 5.43

12.66 ± 9.89

9.7 ± 2.27

0.743

MPRI

1.16 ± 0.18

1.13 ± 0.22

1.09 ± 0.16

1.00 ± 0.17

0.86 ± 0.09*§‡

0.001

Fully quantitative myocardial perfusion

MBF at rest (mL/g/min)

1.32 ± 0.37

1.52 ± 0.80

1.56 ± 0.58

1.55 ± 0.65

1.92 ± 0.63

0.322

MBF at stress (mL/g/min)

1.88 ± 0.48

2.18 ± 0.92

2.24 ± 1.00

2.26 ± 0.97

2.07 ± 0.69

0.760

MPR

1.84 ± 0.29

1.75 ± 0.40

1.58 ± 0.30

1.57 ± 0.28

1.24 ± 0.40*§

0.042

  1. Note: Data expressed as means ± standard deviation (± SD)
  2. MaxSI, maximal signal intensity; PI, perfusion index, MPRI, myocardial perfusion reserve index; MBF, myocardial blood flow; MPR, myocardial perfusion reserve
  3. * P < 0.05 versus before modelling
  4. § P < 0.05 versus 2 months after modelling
  5. P < 0.05 versus 6 months after modelling
  6. # P < 0.05 versus 10 months after modelling