Table 1 Baseline characteristics of experimental animals

Age (months)

16

18

22

26

32

-

Weight (kg)

23.44 ± 5.45

30.18 ± 6.55

36.00 ± 10.59*

42.31 ± 11.74*§

42.36 ± 9.82*§

0.001

FBG (mmol/l)

3.60 ± 0.59

13.15 ± 4.23*

13.36 ± 5.48*

18.10 ± 5.52*§‡

15.20 ± 2.18*

< 0.001

HbA1c (%)

3.01 ± 0.36

3.37 ± 1.02

5.60 ± 1.31*§

4.95 ± 1.45*§

6.08 ± 0.78*§

< 0.001

TC (mmol/l)

5.34 ± 6.09

2.64 ± 0.80

3.73 ± 3.58

3.77 ± 4.81

2.11 ± 0.59

0.258

HDL (mmol/l)

1.14 ± 0.65

0.76 ± 0.36

0.53 ± 0.42

1.08 ± 1.81

0.54 ± 0.24

0.156

LDL (mmol/l)

2.68 ± 3.03

7.24 ± 8.55*

1.98 ± 1.95§

1.85 ± 1.84§

1.27 ± 0.40§

0.215

Creatinine (µmol/l)

70.50 ± 25.08

64.38 ± 14.20

66.20 ± 22.18

39.00 ± 3.61*

51.28 ± 15.75

0.001

Urea (µmol/l)

2.65 ± 1.02

4.30 ± 1.13*

4.94 ± 0.83*

6.01 ± 0.94*§‡

5.40 ± 1.27*

< 0.001

CK-MB (µg/l)

0.37 ± 0.29

0.63 ± 0.73

3.15 ± 2.34*§

3.62 ± 3.17*§

2.83 ± 2.38*§

0.004