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Table 1 Clinical baseline data of patients in the discovery cohort

From: Characterizing the metabolic divide: distinctive metabolites differentiating CAD-T2DM from CAD patients

 

CAD-ONLY

CAD-T2DM

P value

n = 685

n = 254

Demographic data

 Age (years)

62.60 (56.00,70.20)

64.40 (57.55,71.85)

0.030

 Sex (male), %

83.50

72.05

 < 0.001

BMI (kg/m2)

24.00 (22.00,26.00)

24.50 (22.00,27.00)

0.011

Comorbidities

 Hypertension, %

57.08

65.75

0.016

 Hyperlipidemia, %

10.51

12.60

0.365

Biochemical measurements

 ALT, U/L

24.00 (18,34)

24.00 (18,34)

0.633

 AST, U/L

24.00 (20,30)

23.00 (19,30)

0.065

 eGFR, ml/min/1.73 m2

88.81 (74.24,104.60)

87.53 (69.28,103.51)

0.475

 CK, U/L

88.00 (64.00,129.00)

85.00 (57.50,110.00)

0.028

 CKMB, U/L

6.25 (4.50,8.73)

7.00 (5.00,9.20)

0.038

 CREA, μmol/L

83 (71,96)

82 (69,97)

0.611

 CHOL, mmol/L

4.07 (3.49,4.85)

4.18 (3.56,4.91)

0.243

 LDLC, mmol/L

2.44 (1.88,3.16)

2.46 (1.91,3.03)

0.777

 HDLC, mmol/L

0.92 (0.79,1.10)

0.955 (0.79,1.09)

0.799

 APOA, g/L

1.00 (0.86,1.17)

1.01 (0.86,1.20)

0.579

 TG, mmol/L

1.30 (0.97,1.78)

1.48 (1.11,2.11)

 < 0.001

 Lp(a), mg/L

179.40 (86.74,428.64)

178.09 (79.86,361.14)

0.333

 proBNP, pg/mL

197.10 (63.19,672.28)

254.70 (85.75,878.00)

0.082

 GLUC, mmol/L

5.45 (4.90,6.22)

7.90 (6.33,10.84)

 < 0.001

 HbA1c, %

6.00 (5.70,6.30)

7.40 (6.60,8.55)

 < 0.001

  1. Data are shown as median (IQR) or n (%). Chi-square (χ2) tests were used for categorical variables. T-tests or Mann–Whitney U tests were used for normally and non-normally distributed variables, respectively. BMI body mass index, ALT alanine aminotransferase, AST aspartate aminotransferase, eGFR estimated glomerular filtration rate, CK creatine kinase, CKMB MB isoenzyme of creatine kinase, CREA Creatinine, CHOL cholesterol, LDLC low-density lipoprotein cholesterol, HDLC high-density lipoprotein cholesterol, APOA apolipoprotein, TG triacylglycerol, Lp(a): lipoprotein(a), proBNP N-terminal pro-B-type natriuretic peptide, GLUC fasting blood glucose, HbA1c hemoglobin A1c