Fig. 5
From: ASGR1 deficiency diverts lipids toward adipose tissue but results in liver damage during obesity
ASGR1 deficiency enhances the risk for liver inflammation. A Representative 20 × images of H&E staining of WT and ASGR1−/− mice livers after 20 weeks of HFD. Percentage of microsteatosis B and macrosteatosis C in the liver of WT and ASGR1−/− mice after 20 weeks of HFD. D Liver weight after 20 weeks of HFD. E Number of inflammatory foci per field in liver sections of WT and ASGR1−/− mice after 20 weeks of HFD. F Activated canonical pathways (z-score > 2) from the differently expressed proteins in the liver. (G-I) Flow cytometer analysis of immune cells in the liver of WT and ASGR1−/− mice after 20 weeks of HFD expressed number of cells/gr of G natural killer (NK, NK1+), H cytotoxic NK cells (CD27+ CD11b−) and I dendritic cells (DC, CD 11c+). (J) ASGR1 liver protein abundance (Log2-transformed) in patients with different degrees of inflammation (Score_nas_inflammation). K Liver ASGR1 gene expression in patients with obesity, NAFLD and NASH. Each bar and error represent the mean ± SEM