Fig. 4

HOMA-IR, multiterritorial extent of subclinical atherosclerosis, and global plaque volume, stratified by SCORE2 risk category. (A) Number of participants in each SCORE2 risk category, stratified by HOMA-IR category. (B) Extent of subclinical atherosclerosis stratified by SCORE2 risk category. (C) Global plaque volume (absence of disease or plaque volume in tertiles) stratified by SCORE2 risk category. (D) SCORE2 risk-adjusted odds ratios for the multiterritorial extent of subclinical atherosclerosis stratified by HOMA-IR category. (E) Adjusted odds ratios for global plaque volume (absence of disease or plaque volume in tertiles) stratified by HOMA-IR category and SCORE2 risk category. The multivariable models were adjusted for age, sex, smoking status, systolic blood pressure, diastolic blood pressure, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, body mass index, family history of CVD, and HbA1c. OR = odds ratio, SCORE2 = systematic coronary risk evaluation score 2, HOMA-IR = homeostatic model assessment of insulin resistance, 2DVUS = 2-dimensional vascular ultrasound, 3DVUS = 3-dimensional vascular ultrasound