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Table 2 Association between baseline triglyceride-glucose index and risk of total and ischemic stroke

From: Triglyceride-glucose index is associated with a higher risk of stroke in a hypertensive population

TyG index

N

Events (%)

Crude model

Adjusted model*

HR (95%CI)

P

HR (95%CI)

P

Total stroke

 Continuous

7569

288 (3.8)

1.30 (1.07, 1.59)

0.009

1.41 (1.14, 1.75)

0.002

 Quartiles

  Q1 (< 8.5)

1892

63 (3.3)

ref

 

ref

 

  Q2 (8.5–8.8)

1890

58 (3.1)

0.93 (0.65, 1.33)

0.692

1.04 (0.72, 1.51)

0.822

  Q3 (8.8–9.2)

1893

87 (4.6)

1.39 (1.00, 1.92)

0.047

1.43 (1.02, 2.02)

0.039

  Q4 (≥ 9.2)

1894

80 (4.2)

1.27 (0.92, 1.77)

0.151

1.45 (1.01, 2.08)

0.042

 P for trend

   

0.035

 

0.013

 Categories

  Q1–Q2 (< 8.8)

3782

121 (3.2)

ref

 

ref

 

  Q3–Q4 (≥ 8.8)

3787

167 (4.4)

1.38 (1.09,1.74)

0.007

1.41(1.10,1.81)

0.007

 P for trend

   

0.007

 

0.007

Ischemic stroke

 Continuous

7530

248 (3.3)

1.53 (1.24, 1.88)

< 0.001

1.66(1.33, 2.09)

< 0.001

 Quartiles

  Q1 (< 8.5)

1882

43 (2.3)

ref

 

ref

 

  Q2 (8.5–8.8)

1883

51 (2.7)

1.20 (0.80, 1.80)

0.376

1.37(0.90, 2.08)

0.141

  Q3 (8.8–9.2)

1883

79 (4.2)

1.86 (1.28, 2.69)

0.001

1.98(1.34, 2.93)

< 0.001

  Q4 (≥ 9.2)

1882

75 (4.0)

1.76 (1.21, 2.56)

0.003

2.06(1.37, 3.09)

< 0.001

 P for trend

   

< 0.001

 

< 0.001

 Categories

  Q1–Q2 (< 8.8)

3765

94 (2.5)

ref

 

ref

 

  Q3–Q4 (≥ 8.8)

3765

154 (4.1)

1.64 (1.27, 2.12)

< 0.001

1.70 (1.29, 2.24)

< 0.001

 P for trend

   

< 0.001

 

< 0.001

  1. *Adjusted for age, sex, body mass index, systolic blood pressure, diastolic blood pressure, total homocysteine, vitamin B12, estimated glomerular filtration rate, MTHFR C677T, smoking status, alcohol drinking and treatment blood pressure