Table 3 Association of time course of cumulative METS-IR with the risk of cardiovascular disease

Slope

  < 0 (n = 22,444)

1488 (6.63)

6.43(6.11–6.76)

Reference

Reference

Reference

   ≥ 0 (n = 24,826)

1696 (6.83)

6.61(6.30–6.93)

1.18(1.10–1.27)

1.17(1.09–1.26)

1.14(1.07–1.22)

Time course patterns

 Decrease-decrease

536 (6.69)

6.48(5.95–7.05)

Reference

Reference

Reference

 Decrease-increase

1010 (6.75)

6.50(6.11–6.91)

1.13(1.02–1.26)

1.11(1.00–1.24)

1.11(1.00–1.24)

 Increase–decrease

967 (6.56)

6.38(5.99–6.80)

1.08(0.97–1.20)

1.08(0.97–1.20)

1.07(0.96–1.19)

 Increase-increase

671 (7.03)

6.81(6.31–7.35)

1.27(1.13–1.43)

1.25(1.11–1.41)

1.23(1.09–1.38)

Combination cumulative exposure and time course

 CumMETS-IR < median, slope < 0

595 (5.13)

4.87(4.49–5.28)

Reference

Reference

Reference

 CumMETS-IR < median, slope ≥ 0

656 (5.45)

5.15(4.77–5.56)

1.09(0.97–1.21)

1.08(0.96–1.20)

1.07(0.96–1.20)

 CumMETS-IR ≥ median, slope < 0

893 (8.23)

8.17(7.65–8.72)

1.43(1.28–1.58)

1.45(1.31–1.61)

1.38(1.24–1.53)

 CumMETS-IR ≥ median, slope ≥ 0

1040 (8.13)

8.05(7.58–8.56)

1.45(1.31–1.60)

1.45(1.31–1.61)

1.38(1.25–1.53)