Table 2 Association of cumulative exposure to METS-IR with the risk of cardiovascular disease

Cumulative exposure

 Q1 (n = 11,817)

494 (4.18)

3.91(3.58–4.27)

Reference

Reference

Reference

 Q2 (n = 11,818)

757 (6.41)

6.14(5.72–6.59)

1.39(1.24–1.56)

1.40(1.25–1.57)

1.38(1.23–1.54)

 Q3 (n = 11,818)

843 (7.13)

6.95(6.49–7.43)

1.47(1.31–1.64)

1.49(1.33–1.66)

1.44(1.29–1.61)

 Q4 (n = 11,817)

1090 (9.22)

9.30(8.77–9.87)

1.86(1.67–2.07)

1.90(1.71–2.12)

1.77(1.58–1.98)

 P for trend

 < 0.0001

 < 0.0001

 < 0.0001

Exposure duration

 0 year (n = 14,380)

500 (4.53)

4.33(3.96–4.72)

Reference

Reference

Reference

 2 years (n = 7378)

363 (5.49)

5.28(4.77–5.85)

1.18(1.03–1.35)

1.18(1.03–1.35)

1.17(1.02–1.34)

 4 years (n = 7896)

581 (7.49)

7.29(6.72–7.91)

1.56(1.38–1.75)

1.56(1.38–1.76)

1.51(1.34–1.70)

 6 years (n = 17,616)

1740 (7.96)

7.76(7.41–8.14)

1.69(1.53–1.86)

1.70(1.54–1.88)

1.60(1.45–1.77)

 P for trend

 < 0.0001

 < 0.0001

 < 0.0001

Cumulative burden

  < 0 (n = 21,383)

833 (4.86)

4.66(4.35–4.98)

Reference

Reference

Reference

  ≥ 0 (n = 25,887)

2351 (7.80)

7.60(7.30–7.92)

1.55(1.43–1.68)

1.56(1.44–1.69)

1.49(1.37–1.61)