Table 1 Baseline characteristic of the participants according to quartiles of cumulative METS-IR
Characteristics | Overall | Cumulative METS-IR | P value | |||
|---|---|---|---|---|---|---|
Q1 (< 124.84) | Q2 (124.84–142.78) | Q3 (142.79–163.56) | Q4 (≥ 163.57) | |||
No. of participants | 47,270 | 11,817 | 11,818 | 11,818 | 11,817 | Â |
Age, years | 48.87 ± 11.77 | 45.74 ± 11.58 | 48.31 ± 11.37 | 49.84 ± 11.65 | 51.58 ± 11.71 |  < 0.0001 |
Men, n (%) | 36,376 (77.00) | 8307 (70.30) | 9256 (78.32) | 9430 (79.79) | 9383 (79.40) |  < 0.0001 |
High school or above, n (%) | 3461 (7.60) | 1035 (9.04) | 753 (6.60) | 823 (7.24) | 850 (7.49) |  < 0.0001 |
Income ≥ 800yuan/month, n (%) | 6730 (14.80) | 1543 (13.49) | 1574 (13.82) | 1720 (15.15) | 1893 (16.68) |  < 0.0001 |
Current smoker, n (%) | 15,767 (34.30) | 3979 (34.50) | 3948 (34.37) | 3999 (34.90) | 3841 (33.58) | 0.1961 |
Current alcohol, n (%) | 18,113 (39.40) | 4423 (38.35) | 4484 (39.03) | 4610 (40.23) | 4596 (40.13) | 0.0082 |
Active physical activity, n (%) | 6281 (13.30) | 1112 (9.41) | 1374 (11.63) | 1656 (14.01) | 2139 (18.10) |  < 0.0001 |
Hypertension, n (%) | 18,454 (39.00) | 2917 (24.68) | 4349 (36.80) | 5136 (43.46) | 6052 (51.21) |  < 0.0001 |
Diabetes mellitus, n (%) | 3749 (7.90) | 331 (2.80) | 649 (5.49) | 1031 (8.72) | 1738 (14.71) |  < 0.0001 |
Dyslipidemia, n (%) | 16,073 (34.00) | 2082 (17.62) | 3251 (27.51) | 4582 (38.77) | 6158 (52.11) |  < 0.0001 |
Antihypertensive agents, n (%) | 3842 (8.10) | 342 (2.89) | 624 (5.28) | 1015 (8.59) | 1861 (15.75) |  < 0.0001 |
Hypoglycemic agents, n (%) | 856 (1.80) | 67 (0.57) | 124 (1.05) | 206 (1.74) | 459 (3.88) |  < 0.0001 |
Lipid-lowering agents, n (%) | 344 (0.70) | 28 (0.24) | 49 (0.41) | 93 (0.79) | 174 (1.47) |  < 0.0001 |
Body mass index, kg/m2 | 25.06 ± 3.47 | 21.98 ± 2.32 | 24.31 ± 2.43 | 25.94 ± 2.64 | 28.03 ± 3.20 |  < 0.0001 |
Systolic blood pressure, mmHg | 128.30 ± 19.69 | 121.54 ± 18.13 | 127.33 ± 19.07 | 130.31 ± 19.08 | 133.99 ± 20.29 |  < 0.0001 |
Diastolic blood pressure, mmHg | 82.62 ± 11.33 | 78.90 ± 10.66 | 82.16 ± 10.99 | 83.81 ± 10.88 | 85.59 ± 11.69 |  < 0.0001 |
Fasting blood glucose, mg/dL | 97.06 ± 27.34 | 90.70 ± 18.03 | 94.77 ± 23.73 | 98.34 ± 28.61 | 104.44 ± 34.37 |  < 0.0001 |
Total cholesterol, mg/dL | 189.76 ± 43.88 | 186.68 ± 39.49 | 188.35 ± 45.24 | 189.78 ± 46.56 | 194.21 ± 43.55 |  < 0.0001 |
Triglyceride, mg/dL | 149.37 ± 121.9 | 100.98 ± 74.27 | 133.6 ± 100.94 | 161.84 ± 121.72 | 201.08 ± 153.30 |  < 0.0001 |
LDL cholesterol, mg/dL | 88.92 ± 35.29 | 85.56 ± 34.86 | 89.27 ± 34.37 | 90.71 ± 35.42 | 90.17 ± 36.27 |  < 0.0001 |
HDL cholesterol, mg/dL | 59.99 ± 15.25 | 64.47 ± 15.17 | 61.27 ± 14.95 | 58.87 ± 14.98 | 55.33 ± 14.39 |  < 0.0001 |
eGFR, mL/min/1.73m2 | 84.33 ± 25.12 | 87.69 ± 28.16 | 84.15 ± 24.76 | 82.97 ± 23.92 | 82.52 ± 23.02 |  < 0.0001 |
hs-CRP, mg/L | 2.28 ± 6.54 | 1.95 ± 5.17 | 2.09 ± 4.99 | 2.40 ± 8.71 | 2.69 ± 6.55 |  < 0.0001 |