Fig. 3

Hazard ratios and 95% CIs for the association of cumMETS-IR and METS-IR slope with the risk of cardiovascular disease by using restricted cubic spline regression with 4 knots with placed at the 5th, 35th, 65th, and 95th percentiles. CI confidence interval, cumMETS-IR cumulative metabolic score of insulin resistance, METS-IR metabolic score of insulin resistance Adjusted for age, sex, education, income, smoking status, drinking status, physical activity, salt intake, history of hypertension, diabetes, dyslipidemia, total cholesterol, estimated glomerular filtration rate, and high sensitivity C-reactive protein