Fig. 2

Determining cut-off values of time-weight mean METS-IR with distribution and standardized log-rank statistics (left panel), and the incidence of cardiovascular disease according to exposure duration of METS-IR defined by the cut-off values. A. Plots of the distribution time-updated mean METS-IR B. Standardized log-rank statistical C. Incidence rate of cardiovascular disease according to high METS-IR exposure duration D. Hazard ratio and 95% confidence interval for the association of high METS-IR exposure duration with the risk of cardiovascular disease CI confidence interval, cumMETS-IR cumulative metabolic score of insulin resistance Adjusted for age, sex, education, income, smoking status, drinking status, physical activity, salt intake, history of hypertension, diabetes, dyslipidemia, total cholesterol, estimated glomerular filtration rate, and high sensitivity C-reactive protein