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Table 2 Optical Coherence Tomography findings at baseline in the reference segments, the stenosis segment and at strut level

From: Effects of exenatide on coronary stent’s endothelialization in subjects with type 2 diabetes: a randomized controlled trial. The Rebuild study

 

Exenatide (n = 19)

Control (n = 17)

P value

Stent length by OCT, mm

26.3 (20.0–31.4)

28.6 (24.0–40.0)

0.241a

Number of frames per pullback, n

539 (374–540)

539 (374–540)

0.742a

Reference segments

 CS lumen area proximal reference, mm2

9.6 (7.6–12.6)

8.7 (5.9–11.0)

0.158a

 Minimal Lumen Diameter at proximal reference, mm

3 (2.7–3.5)

3 (2.5–3.5)

0.384a

 CS lumen area distal reference, mm2

5.7 (4.6–8.5)

5 (3.3–6.9)

0.334a

 Minimal Lumen Diameter at distal reference, mm

2.6 (2–3.1)

2.3 (1.8–2.8)

0.261a

 Dissection at proximal stent edge, n (%)

0 (0.0)

1 (5.9)

0.472b

 Mean dissection length at proximal stent edge, mm

0 (0.0)

0.05 (0.2)

0.290b

 Dissection at distal stent edge, n (%)

2 (10.5)

1 (5.9)

1.000b

 Mean dissection’s length at distal stent edge, mm

8.4 (7.7–15)

12.1 (7.5–13.2)

0.667a

Stenosis segment

 CS lumen area at maximal obstruction, mm2

6.1 (1.8)

5.1 (1.8)

0.122c

 Lumen area stenosis (mean area as reference), %

23.2 (3.6–32.7)

17.3 (10–27.8)

0.692a

 CS stent area at maximal obstruction, mm2

6.1 (1.8)

5.1 (1.8)

0.097c

 MSA in proximal stent half segment, mm2

7.03 (1.8)

5.9 (1.8)

0.073c

 MSA in distal stent half segment,

6.1 (2.0)

4.8 (1.7)

0.107c

 Mean in-stent CS area, mm2

8.1 (2.2)

7 (2.0)

0.134c

 Stent expansion at MSA, %

75.1 (57.4–87.8)

70.4 (57.7–86.9)

0.704c

 Mean stent expansion, %

116.6 (24.0)

115.9 (18.7)

0.784c

 In-stent stent volume, mm3

157.4 (136–273)

166.5 (104.8–258)

0.537a

Vessel characterization at MSA

Plaque characterization

0.280b

 Fibrotic,n (%)

0 (0.0)

0 (0.0)

 

 Lipidic, n (%)

4 (21.1)

5 (29.4)

 

 Mixed non-calcified, n (%)

4 (21.1)

7 (41.2)

 

 Mixed calcified, n (%)

9 (47.4)

3 (17.6)

 

 Calcification arc, degrees

65.6 (71)

30.6 (51.5)

0.104c

 Calcification deep, mm

0.4 (0.4)

0.2 (0.4)

0.340c

 Thrombus presence, n (%)

7 (36.8)

2 (11.8)

0.128b

 Tissue prolapse, n (%)

10 (52.6)

8 (47.1)

1.000b

 Major tissue prolapse, n (%)

3 (15.8%)

3 (17.6%)

0.895b

Strut analysis

 Total number of struts analyzed per lesion, n

2031 (664)

2545.5 (1187)

0.113c

 Number of struts per cross-section, n

10.2 (1.6)

10.3 (1.4)

0.863c

 Frequency of malapposed struts per lesion, %

5.7 (1.9–12)

5.7 (3.8–13)

0.862a

 Malapposition > 300 µm,%

0.79 (1.5)

1.5 (2.7)

0.347c

 Malapposition volume, mm3

11 (4.8)

13.5 (8.4)

0.285c

 Maximal consecutive length of malapposed struts, mm

1.9 (1.0–3.4)

2 (1.1–3.5)

0.715a

  1. OCT findings at baseline directly after stenting. Tested with aMann-Whitney U test, bFisher’s exact test or Chi2 test, cStudent’s T-test. CS cross-sectional, MSA minimal stent area, OCT Optical Coherence Tomography