Table 1 Baseline clinical characteristics of the randomized participants

Age, years

66.0 (58.2–74.7)

63.0 (55.2–68.0)

0.114^a

Male gender, n (%)

11 (55.0)

11 (61.1)

0.752^b

Indication for angiography, n (%)

0.483^b

 Stable angina

11 (55.0)

7 (38.9)

 Unstable angina

2 (10.0)

4 (22.2)

 NSTEMI

7 (35.0)

7 (38.9)

 Heredity for CV disease, n (%)

1 (5.0)

5 (27.8)

0.177^b

 Current smoking, n (%)

3 (15.0)

2 (11.1)

0.424^b

 Hypertension, n (%)

14.0 (70.0)

14 (77.8)

0.719^b

 Dyslipidemia, n (%)

8 (42.1)

9 (50.0)

0.746^b

 Diabetes duration, years

3.0 (1.0–8.0)

3.5 (0.6–11.5)

0.973^a

 Heart failure, n (%)

5 (25.0)

3 (16.7)

0.697^b

 Myocardial infarction, n (%)

6 (30.0)

6 (33.3)

1.000^b

 CABG, n (%)

3 (15.0)

3 (5.6)

0.606^b

 Simplex retinopathy, n (%)

2 (10.0)

1 (5.6)

1.000^b

 Proliferative diabetic retinopathy, n (%)

1 (5.0)

1 (5.6)

1.000^b

 Diabetic foot, n (%)

0 (0.0)

1 (5.6)

0.474^b

 Stroke, n (%)

3 (15.0)

1 (5.6)

0.606^b

 Atrial fibrillation, n (%)

4 (20.0)

2 (36.0)

0.107^b

 Betablockers, n (%)

15(75.0)

8 (44.4)

0.096^b

 ACEi/ARB, n (%)

12 (60.0)

15 (83.3)

0.160^b

 Statines, n (%)

16 (80.0)

13 (72.2)

0.709^b

 Anticoagulation, n (%)

4 (20.0)

2 (36.0)

0.107^b

 Metformin, n (%)

19 (95.0)

16 (88.9)

0.595^b

 Insulin, n (%)

8 (40.0)

7 (38.9)

0.564^b

 Long-acting insulin, n (%)

7 (35)

6 (33.3)

1.000^b

 Mixed insulin, n (%)

4 (20)

3 (16.7)

1.000^b

 Sulphonylurea, n (%)

0 (0.0)

1 (5.6)

0.309^b

 Thiazolidinediones, n (%)

0 (0.0)

0 (0.0)

-

 SGLT-2-inhibitors, n (%)

0 (0.0)

1 (5.6)

0.309^b

 Weight, kg

93.5 (20.8)

88.1 (12.6)

0.742^c

 BMI, kg/m²

32.0 (30.0–33.0)

29.0 (26.4–31.2)

0.164^a

 Abdominal circumference, cm

114.5 (107.0–123.0)

108.0 (102.0–117.7)

0.203^a

 HbA1c, mmol/mol

60.2 (18.7)

58.8 (14.0)

0.783^c

 HbA1c, % (DCCT)

7.7 (1.7)

7.5 (1.3)

0.787^c

 Hemoglobin, g/L

145.0 (123.7–149.5)

140.0 (132.0–149.0)

0.869^a

 Creatinine, µmol/L

77.0 (14.0)

78.4 (16.0)

0.766^c

 eGFR, ml/min/1,73 m

80.5 (14.4)

84.2(14.6)

0.457^c

 Total cholesterol, mmol/L

4.3 (1.5)

3.9 (1.2)

0.410^c

 LDL cholesterol, mmol/L

1.8 (1.2–3.5)

1.6 (1.2–2.5)

0.427^a

 HDL cholesterol, mmol/L

1.1 (0.8–1.2)

1.0 (0.8–1.6)

0.848^a

 Triglycerides, mmol/L

1.7 (1.2–3.0)

1.7 (1.3–2.5)

0.826^a

 Systolic blood pressure, mmHg

138.0 (24.0)

125.0 (18.0)

0.091^c

 Diastolic blood pressure, mmHg

75.0 (13.0)

77.0 (11.0)

0.644^c

 Heart Rate, bpm

68.0 (10.0)

73.0 (14.0)

0.168^c

Segment in coronary tree, n (%)

0.183^b

 Left Main

3 (15.8)

0 (0.0)

 LAD

11(58.0)

11 (61.1)

 LCX

3 (15.8)

3 (16.7)

 RCA

2 (10.5)

4 (22.2)

 Number of stents, n

1.0 (1.0–2.0)

1.5 (1.0–2.0)

0.331^a

 Stent diameter, mm

3.5 (3.0–4.0)

3.5 (3.3–4.0)

0.687^a

 LVEF by echocardiography, %

55.7 (6.3)

54.7 (11.0)

0.742^c