Fig. 2

Methodology and main results. Panel A to C summarizes the methodology of the study. A: A coronary stenosis in a patient with T2D suitable for stenting is found, dilated, and stented with a Medtronic’s Resolute Onyx^® DES. Then, OCT is performed to ensure optimal stent expansion and vessel wall apposition. B: Participants are randomized to either exenatide (subcutaneous injection once weekly) over standard treatment or standard treatment alone. During the 12 weeks of treatment patients are contacted twice and are interviewed to detect possible adverse events. C: A new coronary angiography including an OCT of the region of interest is performed to assess strut coverage, luminal and stent measurements as well as neo-intima measurements. D: Main results for each treatment group. DES Drug eluting stent, OCT optical coherence tomography, T2D type 2 diabetes, NIT neo-intimal thickness, NIHS neo-intima hyperplasia stenosis