Table 3 Additive effect of increased adiposity and inflammation in incident type 2 diabetes

Model 1

 Increased adiposity

2.15 (2.06‒2.25)

1.78 (1.71‒1.85)

2.47 (2.37‒2.57)

 Increased inflammation

1.16 (1.07‒1.25)

1.16 (1.09‒1.23)

1.15 (1.09‒1.22)

 Joint effect

2.61 (2.48‒2.75)

2.10 (2.00‒2.20)

2.84 (2.70‒2.97)

 RERI

0.30 (0.17‒0.43)

0.16 (0.05‒0.27)

0.22 (0.08‒0.36)

 AP

0.12 (0.07‒0.16)

0.08 (0.03‒0.13)

0.08 (0.03‒0.13)

 S

1.23 (1.12‒1.35)

1.17 (1.05‒1.31)

1.14 (1.04‒1.23)

 Attributable proportion, (%)

  Increased adiposity

71.43

70.91

79.89

  Increased inflammation

9.94

14.55

8.15

  Additive interaction

18.63

14.54

11.96

Model 2

 Increased adiposity

1.77 (1.69‒1.85)

1.67 (1.61‒1.74)

2.03 (1.95‒2.12)

 Elevated inflammation

1.14 (1.06‒1.23)

1.15 (1.08‒1.21)

1.12 (1.07‒1.18)

 Joint effect

2.08 (1.97‒2.19)

1.94 (1.85‒2.03)

2.30 (2.19‒2.42)

 RERI

0.17 (0.05‒0.28)

0.12 (0.02‒0.23)

0.15 (0.02‒0.27)

 AP

0.08 (0.03‒0.14)

0.06 (0.01‒0.12)

0.06 (0.01‒0.11)

 S

1.19 (1.05‒1.34)

1.15 (1.01‒1.30)

1.13 (1.02‒1.24)

 Attributable proportion, (%)

 Increased adiposity

71.30

71.28

79.23

 Increased inflammation

12.96

15.96

9.23

 Additive interaction

15.74

12.76

11.54