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Table 2 Adiposity-associated risks of incident type 2 diabetes in the entire population and across different hsCRP levels

From: Combined effect of adiposity and elevated inflammation on incident type 2 diabetes: a prospective cohort study

 

BMI, HRs (95% CIs)

Waist circumference, HRs (95% CIs)

Fatty liver, HRs (95% CIs)

P-trend

 

BMI < 24 kg/m2

BMI ≥ 24 kg/m2

Non-central obesity

Central obesity

Non-fatty liver

Fatty liver

Entire population

 Event/total

3443/33220

10,835/48952

6446/48935

7832/33237

7169/57611

7109/24561

 

 Incidence rates

10.37

23.82

13.34

25.79

12.60

32.64

 

 Unadjusted model

Reference

2.29 (2.20‒2.38)

Reference

1.93 (1.87‒1.99)

Reference

2.58 (2.50‒2.67)

 < 0.0001

  Model 1

Reference

2.21 (2.12‒2.29)

Reference

1.82 (1.76‒1.89)

Reference

2.50 (2.42‒2.58)

 < 0.0001

  Model 2

Reference

1.76 (1.69‒1.83)

Reference

1.49 (1.44‒1.55)

Reference

2.02 (1.95‒2.09)

 < 0.0001

  Model 3

-

-

Reference

1.16 (1.11‒1.20)

Reference

1.71 (1.64‒1.77)

 < 0.0001

hsCRP < 2 mg/L (9854/60846)

 Event/Total

2573/25937

7281/34909

4947/38859

4907/21987

5307/44386

4547/16460

 

 Incidence rate

9.87

22.17

12.84

24.09

12.03

30.77

 

 Unadjusted model

Reference

2.24 (2.14‒2.34)

Reference

1.88 (1.80‒1.95)

Reference

2.55 (2.45‒2.66)

 < 0.0001

  Model 1

Reference

2.15 (2.05‒2.25)

Reference

1.77 (1.70‒1.85)

Reference

2.46 (2.37‒2.56)

 < 0.0001

   Model 2

Reference

1.75 (1.67‒1.84)

Reference

1.49 (1.43‒1.55)

Reference

2.01 (1.93‒2.10)

 < 0.0001

  Model 3

–

–

Reference

1.14 (1.09‒1.19)

Reference

1.68 (1.61‒1.76)

 < 0.0001

hsCRP ≥ 2 mg/L (4424/21326)

 Event/Total

870/7283

3554/14043

1499/10076

2925/11250

1862/13225

2562/8101

 

 Incidence rate

12.21

28.08

15.32

29.26

14.56

36.61

 

 Unadjusted model

Reference

2.29 (2.12‒2.46)

Reference

1.90 (1.78‒2.02)

Reference

2.49 (2.35‒2.65)

 < 0.0001

  Model 1

Reference

2.24 (2.08‒2.42)

Reference

1.83 (1.71‒1.94)

Reference

2.45 (2.31‒2.60)

 < 0.0001

  Model 2

Reference

1.85 (1.71‒1.99)

Reference

1.55 (1.45‒1.65)

Reference

2.07 (1.94‒2.20)

 < 0.0001

  Model 3

–

–

Reference

1.21 (1.12‒1.30)

Reference

1.76 (1.64‒1.88)

 < 0.0001

  1. Model 1: adjusted for sex, age, smoking habits, alcohol consumption, physical activities, family history of diabetes, antihypertensives, and lipid-lowering drugs
  2. Model 2: further adjusted for log(TG/HDL-C) (continuous), SBP (continuous), and loghsCRP (continuous, entire cohort only)
  3. Model 3: additionally adjusted for BMI (continuous) on the basis of Model 2
  4. The incidence rate is per 1000 person-years
  5. INTm: multiplicative interaction, others as Table 1
  6. P-INTm: BMI subgroups*hsCRP subgroup (< 2, ≥ 2 mg/L) = 0.4978; WC subgroups*hsCRP subgroup (< 2, ≥ 2 mg/L) = 0.8065; Fatty liver subgroup*hsCRP subgroup (< 2, ≥ 2 mg/L) = 0.8043
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Cardiovascular Diabetology

ISSN: 1475-2840